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Anaplastic lymphoma kinase

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Current revision (09:31, 6 October 2013) (edit) (undo)
(Redirecting to Tyrosine kinase)
 
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#REDIRECT [[Tyrosine_kinase]]
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[[Image:2xp2.png|left|200px|thumb|Crystal Structure of human anaplastic lymphoma kinase complex with anti-cancer drug, [[2xp2]]]]
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{{STRUCTURE_2xp2| PDB=2xp2 | SIZE=350| SCENE= |right|CAPTION= Human anaplastic lymphoma kinase complex with anti-cancer drug, [[2xp2]] }}
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'''Anaplastic lymphoma kinase''' (ALK) which is a tyrosine kinase receptor is active in the development of the brain. Chromosomal translocation is observed in ca. 60% anaplastic large-cell lymphomas. The translocation creates a fusion gene composed of the 3’ end of ALK and the 5’ end of nucleophosmin gene. EML4/ALK fusion gene is observed in ca. 4% of non-small-cell lung cancer. Aberrant ALK activity is observed in other carcinomas as well. ALK is comprised by an extracellular domain, a single pass transmembrane domain and an intracellular kinase domain.
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== 3D Structures of anaplastic lymphoma kinase ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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===ALK kinase domain===
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[[2xb7]], [[2xba]], [[3aox]] – hALK + inhibitor – human<br />
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[[3l9p]], [[2yhv]], [[2yjr]], [[2yjs]], [[4fnw]], [[4fnx]], [[4anl]] – hALK (mutant)<br />
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[[3lcs]] – hALK (mutant) + staurosporine<br />
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[[4dce]], [[4fob]], [[4foc]], [[4fod]], [[4fny]], [[4fnz]] – hALK (mutant) + inhibitor<br />
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[[3lct]] – hALK (mutant) + ADP<br />
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[[2xp2]] – hALK + anti-cancer drug<br />
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[[2yfx]], [[4anq]], [[4ans]] – hALK (mutant) + anti-cancer drug<br />
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[[Category:Topic Page]]
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Current revision

  1. REDIRECT Tyrosine_kinase

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Michal Harel, Alexander Berchansky, Jaime Prilusky

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