2gic

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[[Image:2gic.gif|left|200px]]<br /><applet load="2gic" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2gic.gif|left|200px]]
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caption="2gic, resolution 2.920&Aring;" />
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'''Crystal Structure of a vesicular stomatitis virus nucleocapsid-RNA complex'''<br />
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{{Structure
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|PDB= 2gic |SIZE=350|CAPTION= <scene name='initialview01'>2gic</scene>, resolution 2.920&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=IUM:URANYL (VI) ION'>IUM</scene>
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|ACTIVITY=
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|GENE= N ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11277 Vesicular stomatitis Indiana virus])
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}}
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'''Crystal Structure of a vesicular stomatitis virus nucleocapsid-RNA complex'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2GIC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vesicular_stomatitis_indiana_virus Vesicular stomatitis indiana virus] with <scene name='pdbligand=IUM:'>IUM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIC OCA].
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2GIC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vesicular_stomatitis_indiana_virus Vesicular stomatitis indiana virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIC OCA].
==Reference==
==Reference==
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Structure of the vesicular stomatitis virus nucleoprotein-RNA complex., Green TJ, Zhang X, Wertz GW, Luo M, Science. 2006 Jul 21;313(5785):357-60. Epub 2006 Jun 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16778022 16778022]
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Structure of the vesicular stomatitis virus nucleoprotein-RNA complex., Green TJ, Zhang X, Wertz GW, Luo M, Science. 2006 Jul 21;313(5785):357-60. Epub 2006 Jun 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16778022 16778022]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Vesicular stomatitis indiana virus]]
[[Category: Vesicular stomatitis indiana virus]]
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[[Category: protein-rna complex]]
[[Category: protein-rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:31:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:05:00 2008''

Revision as of 15:05, 20 March 2008

Image:2gic.gif


PDB ID 2gic

Drag the structure with the mouse to rotate
, resolution 2.920Å
Ligands:
Gene: N (Vesicular stomatitis Indiana virus)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of a vesicular stomatitis virus nucleocapsid-RNA complex


Overview

Vesicular stomatitis virus is a negative-stranded RNA virus. Its nucleoprotein (N) binds the viral genomic RNA and is involved in multiple functions including transcription, replication, and assembly. We have determined a 2.9 angstrom structure of a complex containing 10 molecules of the N protein and 90 bases of RNA. The RNA is tightly sequestered in a cavity at the interface between two lobes of the N protein. This serves to protect the RNA in the absence of polynucleotide synthesis. For the RNA to be accessed, some conformational change in the N protein should be necessary.

About this Structure

2GIC is a Single protein structure of sequence from Vesicular stomatitis indiana virus. Full crystallographic information is available from OCA.

Reference

Structure of the vesicular stomatitis virus nucleoprotein-RNA complex., Green TJ, Zhang X, Wertz GW, Luo M, Science. 2006 Jul 21;313(5785):357-60. Epub 2006 Jun 15. PMID:16778022

Page seeded by OCA on Thu Mar 20 17:05:00 2008

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