4ja1
From Proteopedia
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{{STRUCTURE_4ja1| PDB=4ja1 | SCENE= }} | {{STRUCTURE_4ja1| PDB=4ja1 | SCENE= }} | ||
===Structure of MMP3 complexed with a platinum-based inhibitor=== | ===Structure of MMP3 complexed with a platinum-based inhibitor=== | ||
| + | {{ABSTRACT_PUBMED_23660647}} | ||
==Disease== | ==Disease== | ||
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==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:023660647</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Stromelysin 1]] | [[Category: Stromelysin 1]] | ||
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[[Category: Natile, G.]] | [[Category: Natile, G.]] | ||
[[Category: Siliqi, D.]] | [[Category: Siliqi, D.]] | ||
| - | [[Category: Hydrolase-hydrolase | + | [[Category: Hydrolase-hydrolase inhibitor complex]] |
[[Category: Matrix metalloprotease]] | [[Category: Matrix metalloprotease]] | ||
Revision as of 16:33, 19 June 2013
Contents |
Structure of MMP3 complexed with a platinum-based inhibitor
Template:ABSTRACT PUBMED 23660647
Disease
[MMP3_HUMAN] Defects in MMP3 are the cause of susceptibility to coronary heart disease type 6 (CHDS6) [MIM:614466]. A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. Note=A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions.[1] [2]
Function
[MMP3_HUMAN] Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
About this Structure
4ja1 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Belviso BD, Caliandro R, Siliqi D, Calderone V, Arnesano F, Natile G. Structure of matrix metalloproteinase-3 with a platinum-based inhibitor. Chem Commun (Camb). 2013 Jun 18;49(48):5492-4. doi: 10.1039/c3cc41278d. Epub 2013, May 10. PMID:23660647 doi:10.1039/c3cc41278d
- ↑ Ye S, Eriksson P, Hamsten A, Kurkinen M, Humphries SE, Henney AM. Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression. J Biol Chem. 1996 May 31;271(22):13055-60. PMID:8662692
- ↑ Yamada Y, Izawa H, Ichihara S, Takatsu F, Ishihara H, Hirayama H, Sone T, Tanaka M, Yokota M. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. N Engl J Med. 2002 Dec 12;347(24):1916-23. PMID:12477941 doi:10.1056/NEJMoa021445
