4bh9

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	==Reference==		==Reference==
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	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Kalodimos, C G.]]		[[Category: Kalodimos, C G.]]
	[[Category: Tzeng, S R.]]		[[Category: Tzeng, S R.]]
	[[Category: Transcription]]		[[Category: Transcription]]

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Revision as of 12:27, 3 July 2013

Template:STRUCTURE 4bh9

Contents 1 A structural model of CAP mutant (T127L and S128I) in the apo state 2 Function 3 About this Structure 4 Reference

A structural model of CAP mutant (T127L and S128I) in the apo state

Template:ABSTRACT PUBMED 23644478

Function

[CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.^[1]

About this Structure

4bh9 is a 1 chain structure with sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

• Tzeng SR, Kalodimos CG. Allosteric inhibition through suppression of transient conformational states. Nat Chem Biol. 2013 May 5. doi: 10.1038/nchembio.1250. PMID:23644478 doi:10.1038/nchembio.1250

1. ↑ Aiba H. Transcription of the Escherichia coli adenylate cyclase gene is negatively regulated by cAMP-cAMP receptor protein. J Biol Chem. 1985 Mar 10;260(5):3063-70. PMID:2982847