4iu6
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_4iu6| PDB=4iu6 | SCENE= }} | {{STRUCTURE_4iu6| PDB=4iu6 | SCENE= }} | ||
===Human Methionine Aminopeptidase in complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1=== | ===Human Methionine Aminopeptidase in complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1=== | ||
| - | {{ | + | {{ABSTRACT_PUBMED_23634668}} |
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
| - | [[4iu6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4iu6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IU6 OCA]. |
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| + | ==See Also== | ||
| + | *[[Aminopeptidase|Aminopeptidase]] | ||
==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:023634668</ref><references group="xtra"/><references/> |
| - | [[Category: | + | [[Category: Human]] |
[[Category: Methionyl aminopeptidase]] | [[Category: Methionyl aminopeptidase]] | ||
[[Category: Amzel, L M.]] | [[Category: Amzel, L M.]] | ||
Revision as of 09:00, 27 November 2013
Contents |
Human Methionine Aminopeptidase in complex with FZ1: Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1
Template:ABSTRACT PUBMED 23634668
Function
[AMPM1_HUMAN] Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle.[1] [2]
About this Structure
4iu6 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.
See Also
Reference
- Zhang F, Bhat S, Gabelli SB, Chen X, Miller MS, Nacev BA, Cheng YL, Meyers DJ, Tenney K, Shim JS, Crews P, Amzel LM, Ma D, Liu JO. Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells. J Med Chem. 2013 May 23;56(10):3996-4016. doi: 10.1021/jm400227z. Epub 2013 May, 1. PMID:23634668 doi:http://dx.doi.org/10.1021/jm400227z
- ↑ Addlagatta A, Hu X, Liu JO, Matthews BW. Structural basis for the functional differences between type I and type II human methionine aminopeptidases. Biochemistry. 2005 Nov 15;44(45):14741-9. PMID:16274222 doi:10.1021/bi051691k
- ↑ Hu X, Addlagatta A, Lu J, Matthews BW, Liu JO. Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18148-53. Epub 2006 Nov 17. PMID:17114291
