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4k9u

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'''Unreleased structure'''
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{{STRUCTURE_4k9u| PDB=4k9u | SCENE= }}
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===Complex of human CYP3A4 with a desoxyritonavir analog===
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The entry 4k9u is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>
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Authors: Sevrioukova, I.F., Poulos, T.L..
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==About this Structure==
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[[4k9u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K9U OCA].
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Description: Complex of human CYP3A4 with a desoxyritonavir analog
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Poulos, T L..]]
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[[Category: Sevrioukova, I F.]]
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[[Category: Alpha-beta protein]]
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[[Category: Cytochrome p450 3a4]]
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[[Category: Cytochrome p450 fold]]
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[[Category: Cytochrome p450 reductase]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Revision as of 07:27, 20 June 2013

Template:STRUCTURE 4k9u

Contents

Complex of human CYP3A4 with a desoxyritonavir analog

Function

[CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.[1]

About this Structure

4k9u is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Miyazawa M, Shindo M, Shimada T. Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes. Drug Metab Dispos. 2001 Feb;29(2):200-5. PMID:11159812

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