2gku
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2gku.gif|left|200px]] | + | [[Image:2gku.gif|left|200px]] |
| - | + | ||
| - | '''Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures''' | + | {{Structure |
| + | |PDB= 2gku |SIZE=350|CAPTION= <scene name='initialview01'>2gku</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2GKU is a [ | + | 2GKU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKU OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold., Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ, J Am Chem Soc. 2006 Aug 2;128(30):9963-70. PMID:[http:// | + | Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold., Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ, J Am Chem Soc. 2006 Aug 2;128(30):9963-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16866556 16866556] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| Line 18: | Line 27: | ||
[[Category: Patel, D J.]] | [[Category: Patel, D J.]] | ||
[[Category: Phan, A T.]] | [[Category: Phan, A T.]] | ||
| - | [[Category: 12 | + | [[Category: 12 structure]] |
[[Category: double-chain reversal loops; nmr]] | [[Category: double-chain reversal loops; nmr]] | ||
[[Category: g-tetrad; 3+1 strand folding;edgewise]] | [[Category: g-tetrad; 3+1 strand folding;edgewise]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:05:51 2008'' |
Revision as of 15:05, 20 March 2008
| |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures
Overview
We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.
About this Structure
2GKU is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold., Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ, J Am Chem Soc. 2006 Aug 2;128(30):9963-70. PMID:16866556
Page seeded by OCA on Thu Mar 20 17:05:51 2008
