4kfz

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'''Unreleased structure'''
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{{STRUCTURE_4kfz| PDB=4kfz | SCENE= }}
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===Crystal structure of LMO2 and anti-LMO2 VH complex===
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{{ABSTRACT_PUBMED_24407558}}
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The entry 4kfz is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN]] A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.
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Authors: Sewell, H., Tanaka, T., El Omari, K., Cruz-Migoni, A., Mancini, E.J., Fuentes-Fernandez, N., Chambers, J., Rabbitts, T.H.
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==Function==
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[[http://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN]] Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
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Description: Crystal structure of LMO2 and anti-LMO2 VH complex
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==About this Structure==
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[[4kfz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFZ OCA].
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==Reference==
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<ref group="xtra">PMID:024407558</ref><references group="xtra"/><references/>
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[[Category: Chambers, J.]]
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[[Category: Cruz-Migoni, A.]]
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[[Category: Fuentes-Fernandez, N.]]
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[[Category: Mancini, E J.]]
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[[Category: Omari, K El.]]
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[[Category: Rabbitts, T H.]]
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[[Category: Sewell, H.]]
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[[Category: Tanaka, T.]]
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[[Category: Developmental protein]]
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[[Category: Lim domain]]
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[[Category: Nucleus]]
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[[Category: Oncoprotein]]
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[[Category: Proto-oncogene]]
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[[Category: T-cell leukemia]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]

Revision as of 06:58, 22 January 2014

Template:STRUCTURE 4kfz

Contents

Crystal structure of LMO2 and anti-LMO2 VH complex

Template:ABSTRACT PUBMED 24407558

Disease

[RBTN2_HUMAN] A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.

Function

[RBTN2_HUMAN] Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.

About this Structure

4kfz is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  • Sewell H, Tanaka T, Omari KE, Mancini EJ, Cruz A, Fernandez-Fuentes N, Chambers J, Rabbitts TH. Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex. Sci Rep. 2014 Jan 10;4:3643. doi: 10.1038/srep03643. PMID:24407558 doi:http://dx.doi.org/10.1038/srep03643

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OCA

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