This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4kfz
From Proteopedia
| Line 1: | Line 1: | ||
| - | + | {{STRUCTURE_4kfz| PDB=4kfz | SCENE= }} | |
| + | ===Crystal structure of LMO2 and anti-LMO2 VH complex=== | ||
| + | {{ABSTRACT_PUBMED_24407558}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN]] A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD. | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/RBTN2_HUMAN RBTN2_HUMAN]] Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. | ||
| - | + | ==About this Structure== | |
| + | [[4kfz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KFZ OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:024407558</ref><references group="xtra"/><references/> | ||
| + | [[Category: Chambers, J.]] | ||
| + | [[Category: Cruz-Migoni, A.]] | ||
| + | [[Category: Fuentes-Fernandez, N.]] | ||
| + | [[Category: Mancini, E J.]] | ||
| + | [[Category: Omari, K El.]] | ||
| + | [[Category: Rabbitts, T H.]] | ||
| + | [[Category: Sewell, H.]] | ||
| + | [[Category: Tanaka, T.]] | ||
| + | [[Category: Developmental protein]] | ||
| + | [[Category: Lim domain]] | ||
| + | [[Category: Nucleus]] | ||
| + | [[Category: Oncoprotein]] | ||
| + | [[Category: Proto-oncogene]] | ||
| + | [[Category: T-cell leukemia]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Transcription factor]] | ||
Revision as of 06:58, 22 January 2014
Contents |
Crystal structure of LMO2 and anti-LMO2 VH complex
Template:ABSTRACT PUBMED 24407558
Disease
[RBTN2_HUMAN] A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.
Function
[RBTN2_HUMAN] Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
About this Structure
4kfz is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- Sewell H, Tanaka T, Omari KE, Mancini EJ, Cruz A, Fernandez-Fuentes N, Chambers J, Rabbitts TH. Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex. Sci Rep. 2014 Jan 10;4:3643. doi: 10.1038/srep03643. PMID:24407558 doi:http://dx.doi.org/10.1038/srep03643
