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4kk2
From Proteopedia
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| - | + | {{STRUCTURE_4kk2| PDB=4kk2 | SCENE= }} | |
| + | ===Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/CHRDS_ARTSI CHRDS_ARTSI]] Condenses two molecules of dimethylallyl diphosphate (DMAPP) to produce mainly an irregular monoterpene, chrysanthemyl diphosphate (CPP) and lower amounts of a branched monoterpene, lavandulyl diphosphate (LPP). CPP is a precursor of the pyrethrin insecticides. When incubated with isopentenyl diphosphate (IPP) and DMAPP, catalyzes three competing isoprenoid condensation reactions, a chain elongation to give geranyl diphosphate (GPP), a cyclopropanation to give CPP and a branching to give LPP.<ref>PMID:12782626</ref> | ||
| - | + | ==About this Structure== | |
| + | [[4kk2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Artemisia_spiciformis Artemisia spiciformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KK2 OCA]. | ||
| - | + | ==Reference== | |
| + | <references group="xtra"/><references/> | ||
| + | [[Category: Artemisia spiciformis]] | ||
| + | [[Category: Almo, S C.]] | ||
| + | [[Category: Bhosle, R.]] | ||
| + | [[Category: Chowdhury, S.]] | ||
| + | [[Category: Evans, B.]] | ||
| + | [[Category: Gerlt, J A.]] | ||
| + | [[Category: Glenn, A Scott.]] | ||
| + | [[Category: Hammonds, J.]] | ||
| + | [[Category: Hillerich, B.]] | ||
| + | [[Category: Imker, H J.]] | ||
| + | [[Category: Initiative, Enzyme Function.]] | ||
| + | [[Category: Love, J.]] | ||
| + | [[Category: Obaidi, N F.Al.]] | ||
| + | [[Category: Poulter, C D.]] | ||
| + | [[Category: Seidel, R D.]] | ||
| + | [[Category: Toro, R.]] | ||
| + | [[Category: Vetting, M W.]] | ||
| + | [[Category: Washington, E.]] | ||
| + | [[Category: Enzyme function initiative]] | ||
| + | [[Category: Isoprenoid synthase]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:27, 20 June 2013
Contents |
Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure
Function
[CHRDS_ARTSI] Condenses two molecules of dimethylallyl diphosphate (DMAPP) to produce mainly an irregular monoterpene, chrysanthemyl diphosphate (CPP) and lower amounts of a branched monoterpene, lavandulyl diphosphate (LPP). CPP is a precursor of the pyrethrin insecticides. When incubated with isopentenyl diphosphate (IPP) and DMAPP, catalyzes three competing isoprenoid condensation reactions, a chain elongation to give geranyl diphosphate (GPP), a cyclopropanation to give CPP and a branching to give LPP.[1]
About this Structure
4kk2 is a 2 chain structure with sequence from Artemisia spiciformis. Full crystallographic information is available from OCA.
Reference
- ↑ Hemmerlin A, Rivera SB, Erickson HK, Poulter CD. Enzymes encoded by the farnesyl diphosphate synthase gene family in the Big Sagebrush Artemisia tridentata ssp. spiciformis. J Biol Chem. 2003 Aug 22;278(34):32132-40. Epub 2003 Jun 2. PMID:12782626 doi:10.1074/jbc.M213045200
Categories: Artemisia spiciformis | Almo, S C. | Bhosle, R. | Chowdhury, S. | Evans, B. | Gerlt, J A. | Glenn, A Scott. | Hammonds, J. | Hillerich, B. | Imker, H J. | Initiative, Enzyme Function. | Love, J. | Obaidi, N F.Al. | Poulter, C D. | Seidel, R D. | Toro, R. | Vetting, M W. | Washington, E. | Enzyme function initiative | Isoprenoid synthase | Structural genomic | Transferase
