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4k98
From Proteopedia
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{{STRUCTURE_4k98| PDB=4k98 | SCENE= }} | {{STRUCTURE_4k98| PDB=4k98 | SCENE= }} | ||
===Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG=== | ===Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG=== | ||
| + | {{ABSTRACT_PUBMED_23647843}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4k98]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K98 OCA]. | [[4k98]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K98 OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023647843</ref><references group="xtra"/><references/> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Gao, P.]] | [[Category: Gao, P.]] | ||
Revision as of 06:02, 28 August 2013
Contents |
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG
Template:ABSTRACT PUBMED 23647843
Function
[CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
About this Structure
4k98 is a 3 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Gao P, Ascano M, Wu Y, Barchet W, Gaffney BL, Zillinger T, Serganov AA, Liu Y, Jones RA, Hartmann G, Tuschl T, Patel DJ. Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell. 2013 May 23;153(5):1094-107. doi: 10.1016/j.cell.2013.04.046. Epub 2013 May, 3. PMID:23647843 doi:10.1016/j.cell.2013.04.046
