This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3ran

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3ran" [edit=sysop:move=sysop])

Revision as of 07:42, 16 May 2013

Template:STRUCTURE 3ran

Contents

CANINE GDP-RAN Q69L MUTANT

Template:ABSTRACT PUBMED 9878368

Function

[RAN_CANFA] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (By similarity).

About this Structure

3ran is a 4 chain structure with sequence from Canis lupus familiaris. Full crystallographic information is available from OCA.

Reference

  • Stewart M, Kent HM, McCoy AJ. The structure of the Q69L mutant of GDP-Ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2). J Mol Biol. 1998 Dec 18;284(5):1517-27. PMID:9878368 doi:10.1006/jmbi.1998.2204

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ran"
Personal tools