3pgb

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{{STRUCTURE_3pgb| PDB=3pgb | SCENE= }}
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==Crystal structure of Aspergillus nidulans amine oxidase==
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===Crystal structure of Aspergillus nidulans amine oxidase===
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<StructureSection load='3pgb' size='340' side='right' caption='[[3pgb]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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{{ABSTRACT_PUBMED_21604787}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3pgb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Emericella_nidulans Emericella nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PGB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPQ:5-(2-CARBOXY-2-AMINOETHYL)-2-HYDROXY-1,4-BENZOQUINONE'>TPQ</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AN6092.2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=162425 Emericella nidulans])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.21 and 1.4.3.22 1.4.3.21 and 1.4.3.22] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pgb RCSB], [http://www.ebi.ac.uk/pdbsum/3pgb PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Aspergillus nidulans amine oxidase (ANAO) has the unusual ability among the family of copper and trihydroxyphenylalanine quinone-containing amine oxidases of being able to oxidize the amine side chains of lysine residues in large peptides and proteins. We show here that in common with the related enzyme from the yeast Pichia pastoris, ANAO can promote the cross-linking of tropoelastin and oxidize the lysine residues in alpha-casein proteins and tropoelastin. The crystal structure of ANAO, the first for a fungal enzyme in this family, has been determined to a resolution of 2.4 A. The enzyme is a dimer with the archetypal fold of a copper-containing amine oxidase. The active site is the most open of any of those of the structurally characterized enzymes in the family and provides a ready explanation for its lysine oxidase-like activity.
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==About this Structure==
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Structure and Activity of Aspergillus nidulans Copper Amine Oxidase.,McGrath AP, Mithieux SM, Collyer CA, Bakhuis JG, van den Berg M, Sein A, Heinz A, Schmelzer C, Weiss AS, Guss JM Biochemistry. 2011 Jun 28;50(25):5718-30. Epub 2011 Jun 3. PMID:21604787<ref>PMID:21604787</ref>
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[[3pgb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Emericella_nidulans Emericella nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGB OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:021604787</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Emericella nidulans]]
[[Category: Emericella nidulans]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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[[Category: Guss, J M.]]
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[[Category: Guss, J M]]
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[[Category: McGrath, A P.]]
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[[Category: McGrath, A P]]
[[Category: Cao]]
[[Category: Cao]]
[[Category: Copper amine oxidase]]
[[Category: Copper amine oxidase]]
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[[Category: Oxidoreductase]]
 
[[Category: Topaquinone]]
[[Category: Topaquinone]]
[[Category: Tpq]]
[[Category: Tpq]]

Revision as of 06:37, 19 December 2014

Crystal structure of Aspergillus nidulans amine oxidase

3pgb, resolution 2.45Å

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