3rq3

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{{STRUCTURE_3rq3| PDB=3rq3 | SCENE= }}
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==Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) in hexagonal crystal form==
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===Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) in hexagonal crystal form===
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<StructureSection load='3rq3' size='340' side='right' caption='[[3rq3]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[3rq3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RQ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RQ3 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/TIGIT_HUMAN TIGIT_HUMAN]] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3q0h|3q0h]]</td></tr>
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==About this Structure==
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TIGIT, VSIG9, VSTM3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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[[3rq3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RQ3 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rq3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rq3 RCSB], [http://www.ebi.ac.uk/pdbsum/3rq3 PDBsum]</span></td></tr>
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</table>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Almo, S C.]]
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[[Category: Almo, S C]]
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[[Category: Guo, H.]]
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[[Category: Guo, H]]
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[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]
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[[Category: IFN, Atoms-to-Animals:.The Immune Function Network]]
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[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Nathenson, S G.]]
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[[Category: Nathenson, S G]]
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[[Category: Ramagopal, U A.]]
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[[Category: Ramagopal, U A]]
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[[Category: Rubinstein, R.]]
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[[Category: Rubinstein, R]]
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[[Category: Samanta, D.]]
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[[Category: Samanta, D]]
[[Category: Adhesion]]
[[Category: Adhesion]]
[[Category: Atoms-to-animals: the immune function network]]
[[Category: Atoms-to-animals: the immune function network]]
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[[Category: Immune receptor]]
[[Category: Immune receptor]]
[[Category: Immune system]]
[[Category: Immune system]]
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[[Category: New york structural genomics research consortium]]
 
[[Category: Nysgrc]]
[[Category: Nysgrc]]
[[Category: Psi-biology]]
[[Category: Psi-biology]]
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[[Category: Structural genomic]]
 
[[Category: Tigit]]
[[Category: Tigit]]

Revision as of 10:25, 19 December 2014

Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) in hexagonal crystal form

3rq3, resolution 2.70Å

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