2wbh

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{{STRUCTURE_2wbh| PDB=2wbh | SCENE= }}
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==Icosahedral particle of covalent coat protein dimer of bacteriophage MS2==
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===ICOSAHEDRAL PARTICLE OF COVALENT COAT PROTEIN DIMER OF BACTERIOPHAGE MS2===
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<StructureSection load='2wbh' size='340' side='right' caption='[[2wbh]], [[Resolution|resolution]] 4.70&Aring;' scene=''>
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{{ABSTRACT_PUBMED_19521994}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2wbh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpms2 Bpms2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WBH FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2b2e|2b2e]], [[6msf|6msf]], [[2bs0|2bs0]], [[2iz9|2iz9]], [[7msf|7msf]], [[2b2g|2b2g]], [[2c4q|2c4q]], [[2c4y|2c4y]], [[1zdj|1zdj]], [[2c4z|2c4z]], [[2c51|2c51]], [[2bny|2bny]], [[1u1y|1u1y]], [[2vtu|2vtu]], [[2bs1|2bs1]], [[1msc|1msc]], [[1mvb|1mvb]], [[2izn|2izn]], [[1mst|1mst]], [[1aq4|1aq4]], [[2ms2|2ms2]], [[2c50|2c50]], [[1zdi|1zdi]], [[1zdk|1zdk]], [[1aq3|1aq3]], [[1mva|1mva]], [[5msf|5msf]], [[2b2d|2b2d]], [[1bms|1bms]], [[1zdh|1zdh]], [[1zse|1zse]], [[2bq5|2bq5]], [[2iz8|2iz8]], [[2izm|2izm]], [[2bu1|2bu1]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wbh RCSB], [http://www.ebi.ac.uk/pdbsum/2wbh PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Particles formed by the bacteriophage MS2 coat protein mutants with insertions in their surface loops induce a strong immune response against the inserted epitopes. The covalent dimers created by fusion of two copies of the coat protein gene are more tolerant to various insertions into the surface loops than the single subunits. We determined a 4.7-A resolution crystal structure of an icosahedral particle assembled from covalent dimers and compared its stability with wild-type virions. The structure resembled the wild-type virion except for the intersubunit linker regions. The covalent dimer orientation was random with respect to both icosahedral twofold and quasi-twofold symmetry axes. A fraction of the particles was unstable in phosphate buffer because of assembly defects. Our results provide a structural background for design of modified covalent coat protein dimer subunits for use in immunization.
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==Function==
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Structure and stability of icosahedral particles of a covalent coat protein dimer of bacteriophage MS2.,Plevka P, Tars K, Liljas L Protein Sci. 2009 Aug;18(8):1653-61. PMID:19521994<ref>PMID:19521994</ref>
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[[http://www.uniprot.org/uniprot/COAT_BPMS2 COAT_BPMS2]] Forms the phage shell; binds to the phage RNA.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[2wbh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_ms2 Enterobacteria phage ms2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBH OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019521994</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Enterobacteria phage ms2]]
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</StructureSection>
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[[Category: Bpms2]]
[[Category: Liljas, L.]]
[[Category: Liljas, L.]]
[[Category: Plevka, P.]]
[[Category: Plevka, P.]]

Revision as of 06:49, 13 August 2014

Icosahedral particle of covalent coat protein dimer of bacteriophage MS2

2wbh, resolution 4.70Å

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