2guc
From Proteopedia
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| - | [[Image:2guc.gif|left|200px]] | + | [[Image:2guc.gif|left|200px]] |
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| - | '''Crystal structure of a complex of griffithsin with mannose at 1.78 A resolution.''' | + | {{Structure |
| + | |PDB= 2guc |SIZE=350|CAPTION= <scene name='initialview01'>2guc</scene>, resolution 1.79Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of a complex of griffithsin with mannose at 1.78 A resolution.''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2GUC is a [ | + | 2GUC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Griffithsia Griffithsia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GUC OCA]. |
==Reference== | ==Reference== | ||
| - | Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding., Ziolkowska NE, O'Keefe BR, Mori T, Zhu C, Giomarelli B, Vojdani F, Palmer KE, McMahon JB, Wlodawer A, Structure. 2006 Jul;14(7):1127-35. PMID:[http:// | + | Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding., Ziolkowska NE, O'Keefe BR, Mori T, Zhu C, Giomarelli B, Vojdani F, Palmer KE, McMahon JB, Wlodawer A, Structure. 2006 Jul;14(7):1127-35. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16843894 16843894] |
[[Category: Griffithsia]] | [[Category: Griffithsia]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: griffithsin]] | [[Category: griffithsin]] | ||
[[Category: hiv]] | [[Category: hiv]] | ||
| - | [[Category: | + | [[Category: lectin]] |
[[Category: mannose binding]] | [[Category: mannose binding]] | ||
| - | [[Category: | + | [[Category: sar]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:09:12 2008'' |
Revision as of 15:09, 20 March 2008
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| , resolution 1.79Å | |||||||
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| Ligands: | , , and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of a complex of griffithsin with mannose at 1.78 A resolution.
Overview
The crystal structure of griffithsin, an antiviral lectin from the red alga Griffithsia sp., was solved and refined at 1.3 A resolution for the free protein and 0.94 A for a complex with mannose. Griffithsin molecules form a domain-swapped dimer, in which two beta strands of one molecule complete a beta prism consisting of three four-stranded sheets, with an approximate 3-fold axis, of another molecule. The structure of each monomer bears close resemblance to jacalin-related lectins, but its dimeric structure is unique. The structures of complexes of griffithsin with mannose and N-acetylglucosamine defined the locations of three almost identical carbohydrate binding sites on each monomer. We have also shown that griffithsin is a potent inhibitor of the coronavirus responsible for severe acute respiratory syndrome (SARS). Antiviral potency of griffithsin is likely due to the presence of multiple, similar sugar binding sites that provide redundant attachment points for complex carbohydrate molecules present on viral envelopes.
About this Structure
2GUC is a Single protein structure of sequence from Griffithsia. Full crystallographic information is available from OCA.
Reference
Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding., Ziolkowska NE, O'Keefe BR, Mori T, Zhu C, Giomarelli B, Vojdani F, Palmer KE, McMahon JB, Wlodawer A, Structure. 2006 Jul;14(7):1127-35. PMID:16843894
Page seeded by OCA on Thu Mar 20 17:09:12 2008
Categories: Griffithsia | Single protein | Wlodawer, A. | Ziolkowska, N E. | ACE | EDO | MAN | SO4 | Domain swapping | Griffithsin | Hiv | Lectin | Mannose binding | Sar
