4gpo
From Proteopedia
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| - | + | ==Oligomeic Turkey Beta1-Adrenergic G Protein-Coupled Receptor== | |
| - | + | <StructureSection load='4gpo' size='340' side='right' caption='[[4gpo]], [[Resolution|resolution]] 3.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4gpo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GPO FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADRB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9103 Meleagris gallopavo])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gpo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gpo RCSB], [http://www.ebi.ac.uk/pdbsum/4gpo PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | G protein-coupled receptors (GPCRs) mediate transmembrane signaling. Before ligand binding, GPCRs exist in a basal state. Crystal structures of several GPCRs bound with antagonists or agonists have been solved. However, the crystal structure of the ligand-free basal state of a GPCR, the starting point of GPCR activation and function, had not yet been determined. Here we report the X-ray crystal structure of the ligand-free basal state of a GPCR in a lipid membrane-like environment. Oligomeric turkey beta1-adrenergic receptors display two dimer interfaces. One interface involves the transmembrane domain (TM) 1, TM2, the C-terminal H8 and extracellular loop 1. The other interface engages residues from TM4, TM5, intracellular loop 2 and extracellular loop 2. Structural comparisons show that this ligand-free state is in an inactive conformation. This provides the structural basis of GPCR dimerization and oligomerization. | ||
| - | + | Crystal structure of oligomeric beta1-adrenergic G protein-coupled receptors in ligand-free basal state.,Huang J, Chen S, Zhang JJ, Huang XY Nat Struct Mol Biol. 2013 Apr;20(4):419-25. doi: 10.1038/nsmb.2504. Epub 2013 Feb, 24. PMID:23435379<ref>PMID:23435379</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | == | + | ==See Also== |
| - | + | *[[Adrenergic receptor|Adrenergic receptor]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Meleagris gallopavo]] | [[Category: Meleagris gallopavo]] | ||
| - | [[Category: Chen, S | + | [[Category: Chen, S]] |
| - | [[Category: Huang, J J | + | [[Category: Huang, J J]] |
| - | [[Category: Huang, X Y | + | [[Category: Huang, X Y]] |
| - | [[Category: Zhang, J J | + | [[Category: Zhang, J J]] |
[[Category: G-protein coupled receptor]] | [[Category: G-protein coupled receptor]] | ||
[[Category: Receptor]] | [[Category: Receptor]] | ||
[[Category: Seven-transmembrane helix receptor]] | [[Category: Seven-transmembrane helix receptor]] | ||
Revision as of 11:31, 21 December 2014
Oligomeic Turkey Beta1-Adrenergic G Protein-Coupled Receptor
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