3rx6

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{{STRUCTURE_3rx6| PDB=3rx6 | SCENE= }}
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==Crystal structure of Polarity Suppression protein from Enterobacteria phage P4==
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===Crystal structure of Polarity Suppression protein from Enterobacteria phage P4===
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<StructureSection load='3rx6' size='340' side='right' caption='[[3rx6]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23150672}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rx6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p4 Enterobacteria phage p4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RX6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">psu ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10680 Enterobacteria phage P4])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rx6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rx6 RCSB], [http://www.ebi.ac.uk/pdbsum/3rx6 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Psu is a capsid decoration protein of bacteriophage P4 and acts as an antiterminator of Rho-dependent transcription termination in bacteria. So far, no structures have been reported for the Psu protein or its homologues. Here, we report the first structure of Psu solved by the Hg(2+) single wavelength anomalous dispersion method, which reveals that Psu exists as a knotted homodimer and is first of its kind in nature. Each monomer of Psu attains a novel fold around a tight coiled-coil motif. CD spectroscopy and the structure of an engineered disulfide-bridged Psu derivative reveal that the protein folds reversibly and reassembles by itself into the knotted dimeric conformation without the requirement of any chaperone. This structure would help to explain the functional properties of the protein and can be used as a template to design a minimal peptide fragment that can be used as a drug against Rho-dependent transcription termination in bacteria.
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==Function==
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The first structure of polarity suppression protein, Psu from enterobacteria phage P4, reveals a novel fold and a knotted dimer.,Banerjee R, Nath S, Ranjan A, Khamrui S, Pani B, Sen R, Sen U J Biol Chem. 2012 Dec 28;287(53):44667-75. doi: 10.1074/jbc.M112.423202. Epub, 2012 Nov 12. PMID:23150672<ref>PMID:23150672</ref>
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[[http://www.uniprot.org/uniprot/VPSU_BPP4 VPSU_BPP4]] Late protein which functions to suppress polarity of amber mutations in the late genes of the P2 helper phage.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3rx6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p4 Enterobacteria phage p4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RX6 OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023150672</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Enterobacteria phage p4]]
[[Category: Enterobacteria phage p4]]
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[[Category: Banerjee, R.]]
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[[Category: Banerjee, R]]
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[[Category: Khamrui, S.]]
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[[Category: Khamrui, S]]
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[[Category: Nath, S.]]
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[[Category: Nath, S]]
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[[Category: Sen, R.]]
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[[Category: Sen, R]]
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[[Category: Sen, U.]]
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[[Category: Sen, U]]
[[Category: All alpha protein]]
[[Category: All alpha protein]]
[[Category: Capsid decoration protein of bacteriophage p4]]
[[Category: Capsid decoration protein of bacteriophage p4]]

Revision as of 10:52, 19 December 2014

Crystal structure of Polarity Suppression protein from Enterobacteria phage P4

3rx6, resolution 2.04Å

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