3qsy

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{{STRUCTURE_3qsy| PDB=3qsy | SCENE= }}
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==Recognition of the methionylated initiator tRNA by the translation initiation factor 2 in Archaea==
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===Recognition of the methionylated initiator tRNA by the translation initiation factor 2 in Archaea===
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<StructureSection load='3qsy' size='340' side='right' caption='[[3qsy]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23291527}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qsy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QSY FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">eif2g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091]), eif2a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 ATCC 35091])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qsy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qsy RCSB], [http://www.ebi.ac.uk/pdbsum/3qsy PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Heterotrimeric aIF2alphabetagamma (archaeal homologue of the eukaryotic translation initiation factor 2) in its GTP-bound form delivers Met-tRNA(i)(Met) to the small ribosomal subunit. It is known that the heterodimer containing the GTP-bound gamma subunit and domain 3 of the alpha subunit of aIF2 is required for the formation of a stable complex with Met-tRNA(i). Here, the crystal structure of an incomplete ternary complex including aIF2alphaD3gammaGDPNPMet-tRNA(f)(Met) has been solved at 3.2A resolution. This structure is in good agreement with biochemical and hydroxyl radical probing data. The analysis of the complex shows that despite the structural similarity of aIF2gamma and the bacterial translation elongation factor EF-Tu, their modes of tRNA binding are very different. Remarkably, the recently published 5.0-A-resolution structure of almost the same ternary initiation complex differs dramatically from the structure presented. Reasons for this discrepancy are discussed.
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==Function==
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Crystal Structure of the Archaeal Translation Initiation Factor 2 in Complex with a GTP Analogue and Met-tRNA(f)(Met).,Stolboushkina E, Nikonov S, Zelinskaya N, Arkhipova V, Nikulin A, Garber M, Nikonov O J Mol Biol. 2013 Jan 3. pii: S0022-2836(12)00971-0. doi:, 10.1016/j.jmb.2012.12.023. PMID:23291527<ref>PMID:23291527</ref>
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[[http://www.uniprot.org/uniprot/IF2G_SULSO IF2G_SULSO]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity). [[http://www.uniprot.org/uniprot/IF2A_SULSO IF2A_SULSO]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity).
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[3qsy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QSY OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023291527</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
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[[Category: Atcc 35091]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Sulfolobus solfataricus]]
 
[[Category: Garber, M B.]]
[[Category: Garber, M B.]]
[[Category: Nikonov, O S.]]
[[Category: Nikonov, O S.]]

Revision as of 03:23, 4 September 2014

Recognition of the methionylated initiator tRNA by the translation initiation factor 2 in Archaea

3qsy, resolution 3.20Å

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