2m8d

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'''Unreleased structure'''
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{{STRUCTURE_2m8d| PDB=2m8d | SCENE= }}
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===Structure of SRSF1 RRM2 in complex with the RNA 5'-UGAAGGAC-3'===
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The entry 2m8d is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/SRSF1_HUMAN SRSF1_HUMAN]] Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors.<ref>PMID:8223481</ref> <ref>PMID:8139654</ref>
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Authors: Clery, A., Sinha, R., Anczukow, O., Corrionero, A., Moursy, A., Daubner, G., Valcarcel, J., Krainer, A.R., Allain, F.H.T.
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==About this Structure==
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[[2m8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M8D OCA].
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Description: Structure of SRSF1 RRM2 in complex with the RNA 5'-UGAAGGAC-3'
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Allain, F H.T.]]
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[[Category: Anczukow, O.]]
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[[Category: Clery, A.]]
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[[Category: Corrionero, A.]]
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[[Category: Daubner, G.]]
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[[Category: Krainer, A R.]]
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[[Category: Moursy, A.]]
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[[Category: Sinha, R.]]
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[[Category: Valcarcel, J.]]
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[[Category: Pseudo-rrm]]
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[[Category: Rna binding protein-rna complex]]
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[[Category: Rrm]]
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[[Category: Sr protein]]

Revision as of 15:46, 10 July 2013

Template:STRUCTURE 2m8d

Contents

Structure of SRSF1 RRM2 in complex with the RNA 5'-UGAAGGAC-3'

Function

[SRSF1_HUMAN] Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors.[1] [2]

About this Structure

2m8d is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  1. ↑ Zuo P, Manley JL. Functional domains of the human splicing factor ASF/SF2. EMBO J. 1993 Dec;12(12):4727-37. PMID:8223481
  2. ↑ Kohtz JD, Jamison SF, Will CL, Zuo P, Luhrmann R, Garcia-Blanco MA, Manley JL. Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors. Nature. 1994 Mar 10;368(6467):119-24. PMID:8139654 doi:http://dx.doi.org/10.1038/368119a0

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