3w9j

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'''Unreleased structure'''
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{{STRUCTURE_3w9j| PDB=3w9j | SCENE= }}
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===Structural basis for the inhibition of bacterial multidrug exporters===
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The entry 3w9j is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/MEXB_PSEAE MEXB_PSEAE]] The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref> The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref>
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Authors: Sakurai, K., Nakashima, R., Hayashi, K., Yamaguchi, A.
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==About this Structure==
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[[3w9j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W9J OCA].
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Description: Structural basis for the inhibition of bacterial multidrug exporters
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Pseudomonas aeruginosa pao1]]
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[[Category: Hayashi, K.]]
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[[Category: Nakashima, R.]]
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[[Category: Sakurai, K.]]
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[[Category: Yamaguchi, A.]]
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[[Category: Efflux pump]]
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[[Category: Inner membrane]]
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[[Category: Membrane protein]]
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[[Category: Mexa]]
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[[Category: Mexb]]
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[[Category: Multidrug efflux pump]]
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[[Category: Oprm]]
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[[Category: Transport protein]]
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[[Category: Transporter]]

Revision as of 14:12, 3 July 2013

Template:STRUCTURE 3w9j

Contents

Structural basis for the inhibition of bacterial multidrug exporters

Function

[MEXB_PSEAE] The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine.[1] [2] [3] The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.[4] [5] [6]

About this Structure

3w9j is a 6 chain structure with sequence from Pseudomonas aeruginosa pao1. Full crystallographic information is available from OCA.

Reference

  1. ↑ Poole K, Krebes K, McNally C, Neshat S. Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon. J Bacteriol. 1993 Nov;175(22):7363-72. PMID:8226684
  2. ↑ Li XZ, Nikaido H, Poole K. Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1995 Sep;39(9):1948-53. PMID:8540696
  3. ↑ Li XZ, Zhang L, Poole K. Role of the multidrug efflux systems of Pseudomonas aeruginosa in organic solvent tolerance. J Bacteriol. 1998 Jun;180(11):2987-91. PMID:9603892
  4. ↑ Poole K, Krebes K, McNally C, Neshat S. Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon. J Bacteriol. 1993 Nov;175(22):7363-72. PMID:8226684
  5. ↑ Li XZ, Nikaido H, Poole K. Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1995 Sep;39(9):1948-53. PMID:8540696
  6. ↑ Li XZ, Zhang L, Poole K. Role of the multidrug efflux systems of Pseudomonas aeruginosa in organic solvent tolerance. J Bacteriol. 1998 Jun;180(11):2987-91. PMID:9603892

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