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4bqs

From Proteopedia

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m (Protected "4bqs" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4bqs| PDB=4bqs | SCENE= }}
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===Crystal structure of Mycobacterium tuberculosis shikimate kinase in complex with ADP and a shikimic acid derivative.===
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{{ABSTRACT_PUBMED_23889343}}
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The entry 4bqs is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/AROK_MYCTU AROK_MYCTU]] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:11483005</ref> <ref>PMID:17020768</ref>
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Authors: Otero, J.M., Garcia-Doval, C., Llamas-Saiz, A.L., Blanco, B., Prado, V., Lence, E., Lamb, H., Hawkins, A.R., Gonzalez-Bello, C., vanRaaij, M.J.
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==About this Structure==
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[[4bqs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQS OCA].
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Description: Crystal structure of Mycobacterium tuberculosis shikimate kinase in complex with ADP and a shikimic acid derivative.
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==Reference==
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<ref group="xtra">PMID:023889343</ref><references group="xtra"/><references/>
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Shikimate kinase]]
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[[Category: Blanco, B.]]
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[[Category: Garcia-Doval, C.]]
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[[Category: Gonzalez-Bello, C.]]
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[[Category: Hawkins, A R.]]
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[[Category: Lamb, H.]]
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[[Category: Lence, E.]]
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[[Category: Llamas-Saiz, A L.]]
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[[Category: Otero, J M.]]
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[[Category: Prado, V.]]
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[[Category: VanRaaij, M J.]]
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[[Category: Inhibitor]]
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[[Category: Shikimic acid pathway]]
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[[Category: Transferase]]

Revision as of 20:52, 7 August 2013

Template:STRUCTURE 4bqs

Contents

Crystal structure of Mycobacterium tuberculosis shikimate kinase in complex with ADP and a shikimic acid derivative.

Template:ABSTRACT PUBMED 23889343

Function

[AROK_MYCTU] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.[1] [2]

About this Structure

4bqs is a 3 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

  • Blanco B, Prado V, Lence E, Otero JM, Garcia-Doval C, van Raaij MJ, Llamas-Saiz AL, Lamb H, Hawkins AR, Gonzalez-Bello C. Mycobacterium tuberculosis Shikimate Kinase Inhibitors: Design and Simulation Studies of the Catalytic Turnover J Am Chem Soc. 2013 Jul 26. PMID:23889343 doi:10.1021/ja405853p</li></ul>
  1. ↑ Oliveira JS, Pinto CA, Basso LA, Santos DS. Cloning and overexpression in soluble form of functional shikimate kinase and 5-enolpyruvylshikimate 3-phosphate synthase enzymes from Mycobacterium tuberculosis. Protein Expr Purif. 2001 Aug;22(3):430-5. PMID:11483005 doi:10.1006/prep.2001.1457
  2. ↑ Hartmann MD, Bourenkov GP, Oberschall A, Strizhov N, Bartunik HD. Mechanism of phosphoryl transfer catalyzed by shikimate kinase from Mycobacterium tuberculosis. J Mol Biol. 2006 Dec 1;364(3):411-23. Epub 2006 Sep 5. PMID:17020768 doi:10.1016/j.jmb.2006.09.001

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