4jz0

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'''Unreleased structure'''
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{{STRUCTURE_4jz0| PDB=4jz0 | SCENE= }}
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===X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with CTT1055===
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The entry 4jz0 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/FOLH1_HUMAN FOLH1_HUMAN]] Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
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Authors: Barinka, C.
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==About this Structure==
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[[4jz0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JZ0 OCA].
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Description: X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with CTT1055
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[[Category: Glutamate carboxypeptidase II]]
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[[Category: Barinka, C.]]
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[[Category: Hydrolase]]
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[[Category: Metallopeptidase]]

Revision as of 09:32, 2 April 2014

Template:STRUCTURE 4jz0

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with CTT1055

Function

[FOLH1_HUMAN] Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

About this Structure

4jz0 is a 1 chain structure. Full crystallographic information is available from OCA.

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OCA

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