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4k5h

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'''Unreleased structure'''
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{{STRUCTURE_4k5h| PDB=4k5h | SCENE= }}
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===Structure of bovine endothelial nitric oxide synthase heme domain in complex with (S)-1,2-bis((2-amino-4-methylpyridin-6-yl)-methoxy)-propan-3-amine===
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{{ABSTRACT_PUBMED_23993333}}
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The entry 4k5h is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
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Authors: Chreifi, G., Li, H., Poulos, T.L.
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==About this Structure==
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[[4k5h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K5H OCA].
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Description: Structure of bovine endothelial nitric oxide synthase heme domain in complex with (S)-1,2-bis((2-amino-4-methylpyridin-6-yl)-methoxy)-propan-3-amine
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==Reference==
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<ref group="xtra">PMID:023993333</ref><references group="xtra"/><references/>
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[[Category: Bos taurus]]
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[[Category: Chreifi, G.]]
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[[Category: Li, H.]]
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[[Category: Poulos, T L.]]
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[[Category: Nitric oxide synthase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Revision as of 04:08, 20 September 2013

Template:STRUCTURE 4k5h

Contents

Structure of bovine endothelial nitric oxide synthase heme domain in complex with (S)-1,2-bis((2-amino-4-methylpyridin-6-yl)-methoxy)-propan-3-amine

Template:ABSTRACT PUBMED 23993333

Function

[NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

About this Structure

4k5h is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

  • Jing Q, Li H, Chreifi G, Roman LJ, Martasek P, Poulos TL, Silverman RB. Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5674-9. doi: 10.1016/j.bmcl.2013.08.034., Epub 2013 Aug 14. PMID:23993333 doi:10.1016/j.bmcl.2013.08.034

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OCA

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