This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4kcs

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4kcs| PDB=4kcs | SCENE= }}
 +
===Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-(3-((ethyl(3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide===
 +
{{ABSTRACT_PUBMED_24447275}}
-
The entry 4kcs is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
-
Authors: Chreifi, G., Li, H., Poulos, T.L.
+
==About this Structure==
 +
[[4kcs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KCS OCA].
-
Description: Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-(3-((ethyl(3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide
+
==Reference==
 +
<ref group="xtra">PMID:024447275</ref><references group="xtra"/><references/>
 +
[[Category: Chreifi, G.]]
 +
[[Category: Li, H.]]
 +
[[Category: Poulos, T L.]]
 +
[[Category: Nitric oxide synthase]]
 +
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Revision as of 05:03, 13 February 2014

Template:STRUCTURE 4kcs

Contents

Structure of bovine endothelial nitric oxide synthase heme domain in complex with N-(3-((ethyl(3-fluorophenethyl)amino)methyl)phenyl)thiophene-2-carboximidamide

Template:ABSTRACT PUBMED 24447275

Function

[NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

About this Structure

4kcs is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Huang H, Li H, Yang S, Chreifi G, Martasek P, Roman LJ, Meyskens FL, Poulos TL, Silverman RB. Potent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma. J Med Chem. 2014 Jan 30. PMID:24447275 doi:http://dx.doi.org/10.1021/jm401252e

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4kcs"
Personal tools