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4kkx

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'''Unreleased structure'''
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{{STRUCTURE_4kkx| PDB=4kkx | SCENE= }}
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===Crystal structure of Tryptophan Synthase from Salmonella typhimurium with 2-aminophenol quinonoid in the beta site and the F6 inhibitor in the alpha site===
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{{ABSTRACT_PUBMED_23952479}}
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The entry 4kkx is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/TRPA_SALTY TRPA_SALTY]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [[http://www.uniprot.org/uniprot/TRPB_SALTY TRPB_SALTY]] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
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Authors: Hilario, E., Niks, D., Dunn, M.F., Mueller, L.J., Fan, L.
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==About this Structure==
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[[4kkx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KKX OCA].
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Description: Crystal structure of Tryptophan Synthase from Salmonella typhimurium with 2-aminophenol quinonoid in the beta site and the F6 inhibitor in the alpha site
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==Reference==
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<ref group="xtra">PMID:023952479</ref><references group="xtra"/><references/>
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[[Category: Tryptophan synthase]]
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[[Category: Dunn, M F.]]
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[[Category: Fan, L.]]
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[[Category: Hilario, E.]]
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[[Category: Mueller, L J.]]
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[[Category: Niks, D.]]
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[[Category: 2-aminophenol quinonoid]]
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[[Category: Allosteric enzyme]]
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[[Category: Aromatic amino acid biosynthesis]]
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[[Category: Biosynthesis]]
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[[Category: Carbon-oxygen lyase]]
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[[Category: F6f]]
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[[Category: Lyase]]
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[[Category: Lyase-lyase inhibitor complex]]
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[[Category: Pyridoxal phosphate]]
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[[Category: Tryptophan biosynthesis]]

Revision as of 12:09, 1 January 2014

Template:STRUCTURE 4kkx

Contents

Crystal structure of Tryptophan Synthase from Salmonella typhimurium with 2-aminophenol quinonoid in the beta site and the F6 inhibitor in the alpha site

Template:ABSTRACT PUBMED 23952479

Function

[TRPA_SALTY] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [TRPB_SALTY] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

About this Structure

4kkx is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Niks D, Hilario E, Dierkers A, Ngo H, Borchardt D, Neubauer TJ, Fan L, Mueller LJ, Dunn MF. Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states. Biochemistry. 2013 Sep 17;52(37):6396-411. doi: 10.1021/bi400795e. Epub 2013 Sep , 6. PMID:23952479 doi:http://dx.doi.org/10.1021/bi400795e

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OCA

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