4kp3

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m (Protected "4kp3" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4kp3| PDB=4kp3 | SCENE= }}
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===Crystal Structure of MyoVa-GTD in Complex with Two Cargos===
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{{ABSTRACT_PUBMED_23798443}}
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The entry 4kp3 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/MYO5A_MOUSE MYO5A_MOUSE]] Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.<ref>PMID:22908308</ref> [[http://www.uniprot.org/uniprot/MELPH_MOUSE MELPH_MOUSE]] Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.<ref>PMID:11887186</ref> [[http://www.uniprot.org/uniprot/RIPL2_MOUSE RIPL2_MOUSE]] Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. May activate RAC1 (By similarity).
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Authors: Wei, Z., Liu, X., Yu, C., Zhang, M.
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==About this Structure==
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[[4kp3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP3 OCA].
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Description: Crystal Structure of MyoVa-GTD in Complex with Two Cargos
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==Reference==
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<ref group="xtra">PMID:023798443</ref><references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: Liu, X.]]
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[[Category: Wei, Z.]]
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[[Category: Yu, C.]]
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[[Category: Zhang, M.]]
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[[Category: Helix bundle]]
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[[Category: Motor protein-protein transport complex]]

Revision as of 15:42, 10 July 2013

Template:STRUCTURE 4kp3

Contents

Crystal Structure of MyoVa-GTD in Complex with Two Cargos

Template:ABSTRACT PUBMED 23798443

Function

[MYO5A_MOUSE] Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.[1] [MELPH_MOUSE] Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.[2] [RIPL2_MOUSE] Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. May activate RAC1 (By similarity).

About this Structure

4kp3 is a 6 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Wei Z, Liu X, Yu C, Zhang M. Structural basis of cargo recognitions for class V myosins. Proc Natl Acad Sci U S A. 2013 Jun 24. PMID:23798443 doi:10.1073/pnas.1306768110
  1. ↑ Chen Y, Wang Y, Zhang J, Deng Y, Jiang L, Song E, Wu XS, Hammer JA, Xu T, Lippincott-Schwartz J. Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes. J Cell Biol. 2012 Aug 20;198(4):545-60. doi: 10.1083/jcb.201111091. PMID:22908308 doi:10.1083/jcb.201111091
  2. ↑ Wu XS, Rao K, Zhang H, Wang F, Sellers JR, Matesic LE, Copeland NG, Jenkins NA, Hammer JA 3rd. Identification of an organelle receptor for myosin-Va. Nat Cell Biol. 2002 Apr;4(4):271-8. PMID:11887186 doi:10.1038/ncb760

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