4kuc

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m (Protected "4kuc" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4kuc| PDB=4kuc | SCENE= }}
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===Crystal structure of ricin-A chain in complex with the antibody 6C2===
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The entry 4kuc is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO]] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).
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Authors: Zhu, Y., Li, X., Teng, M.
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==About this Structure==
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[[4kuc]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KUC OCA].
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Description: Crystal structure of ricin-A chain in complex with the antibody 6C2
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[[Category: Mus musculus]]
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[[Category: Ricinus communis]]
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[[Category: RRNA N-glycosylase]]
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[[Category: Li, X.]]
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[[Category: Teng, M.]]
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[[Category: Zhu, Y.]]
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[[Category: Hydrolase-immune system complex]]
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[[Category: Rna-n-glycosidase]]

Revision as of 05:13, 18 July 2013

Template:STRUCTURE 4kuc

Crystal structure of ricin-A chain in complex with the antibody 6C2

Function

[RICI_RICCO] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).

About this Structure

4kuc is a 6 chain structure with sequence from Mus musculus and Ricinus communis. Full crystallographic information is available from OCA.

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OCA

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