4kux

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4kux" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4kux| PDB=4kux | SCENE= }}
 +
===Crystal structure of Aspergillus terreus aristolochene synthase complexed with farnesyl thiolodiphosphate (FSPP)===
 +
{{ABSTRACT_PUBMED_23905850}}
-
The entry 4kux is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/ARIS_ASPTE ARIS_ASPTE]] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce aristolochene. Aristolochene is the likely parent compound for a number of sesquiterpenoid toxins produced by filamentous fungi.<ref>PMID:10775423</ref> <ref>PMID:15186158</ref>
-
Authors: Chen, M., Faraldos, J.A., Al-lami, N., Janvier, M., D'Antonio, E.L., Cane, D.E., Allemann, R.K., Christianson, D.W.
+
==About this Structure==
 +
[[4kux]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_terreus Aspergillus terreus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KUX OCA].
-
Description: Crystal structure of Aspergillus terreus aristolochene synthase complexed with farnesyl thiolodiphosphate (FSPP)
+
==Reference==
 +
<ref group="xtra">PMID:023905850</ref><references group="xtra"/><references/>
 +
[[Category: Aristolochene synthase]]
 +
[[Category: Aspergillus terreus]]
 +
[[Category: Al-lami, N.]]
 +
[[Category: Allemann, R K.]]
 +
[[Category: Antonio, E L.D.]]
 +
[[Category: Cane, D E.]]
 +
[[Category: Chen, M.]]
 +
[[Category: Christianson, D W.]]
 +
[[Category: Faraldos, J A.]]
 +
[[Category: Janvier, M.]]
 +
[[Category: Class i terpene cyclase]]
 +
[[Category: Lyase]]

Revision as of 07:54, 14 August 2013

Template:STRUCTURE 4kux

Contents

Crystal structure of Aspergillus terreus aristolochene synthase complexed with farnesyl thiolodiphosphate (FSPP)

Template:ABSTRACT PUBMED 23905850

Function

[ARIS_ASPTE] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce aristolochene. Aristolochene is the likely parent compound for a number of sesquiterpenoid toxins produced by filamentous fungi.[1] [2]

About this Structure

4kux is a 4 chain structure with sequence from Aspergillus terreus. Full crystallographic information is available from OCA.

Reference

  • Chen M, Al-Lami N, Janvier M, D'Antonio EL, Faraldos JA, Cane DE, Allemann RK, Christianson DW. Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase. Biochemistry. 2013 Aug 13;52(32):5441-53. doi: 10.1021/bi400691v. Epub 2013 Aug, 1. PMID:23905850 doi:10.1021/bi400691v
  1. ↑ Cane DE, Kang I. Aristolochene synthase: purification, molecular cloning, high-level expression in Escherichia coli, and characterization of the Aspergillus terreus cyclase. Arch Biochem Biophys. 2000 Apr 15;376(2):354-64. PMID:10775423 doi:10.1006/abbi.2000.1734
  2. ↑ Felicetti B, Cane DE. Aristolochene synthase: mechanistic analysis of active site residues by site-directed mutagenesis. J Am Chem Soc. 2004 Jun 16;126(23):7212-21. PMID:15186158 doi:10.1021/ja0499593

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4kux"
Personal tools