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4ky8

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4ky8| PDB=4ky8 | SCENE= }}
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===Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, methotrexate, FdUMP and 4-((2-amino-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)thio)-2-chlorophenyl)-L-glutamic acid===
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{{ABSTRACT_PUBMED_23927969}}
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The entry 4ky8 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/Q5CGA3_CRYHO Q5CGA3_CRYHO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]
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Authors: Kumar, V.P., Anderson, K.S.
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==About this Structure==
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[[4ky8]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryptosporidium_hominis Cryptosporidium hominis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KY8 OCA].
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Description: Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, methotrexate, FdUMP and 4-((2-amino-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)thio)-2-chlorophenyl)-L-glutamic acid
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==Reference==
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<ref group="xtra">PMID:023927969</ref><references group="xtra"/><references/>
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[[Category: Cryptosporidium hominis]]
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[[Category: Anderson, K S.]]
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[[Category: Kumar, V P.]]
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[[Category: Bifunctional enzyme]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-inhibitor complex]]
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[[Category: Transferase]]

Revision as of 08:25, 21 August 2013

Template:STRUCTURE 4ky8

Contents

Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, methotrexate, FdUMP and 4-((2-amino-6-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)thio)-2-chlorophenyl)-L-glutamic acid

Template:ABSTRACT PUBMED 23927969

Function

[Q5CGA3_CRYHO] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]

About this Structure

4ky8 is a 5 chain structure with sequence from Cryptosporidium hominis. Full crystallographic information is available from OCA.

Reference

  • Kumar VP, Frey KM, Wang Y, Jain HK, Gangjee A, Anderson KS. Substituted pyrrolo[2,3-d]pyrimidines as Cryptosporidium hominis thymidylate synthase inhibitors. Bioorg Med Chem Lett. 2013 Jul 24. pii: S0960-894X(13)00882-2. doi:, 10.1016/j.bmcl.2013.07.037. PMID:23927969 doi:10.1016/j.bmcl.2013.07.037

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OCA

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