4kyh

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m (Protected "4kyh" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4kyh| PDB=4kyh | SCENE= }}
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===Crystal structure of mouse glyoxalase I complexed with zopolrestat===
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{{ABSTRACT_PUBMED_23857942}}
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The entry 4kyh is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/LGUL_MOUSE LGUL_MOUSE]] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity).
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Authors: Zhai, J., Yuan, M., Zhang, L., Chen, Y., Zhang, H., Chen, S., Zhao, Y.
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==About this Structure==
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[[4kyh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KYH OCA].
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Description: Crystal structure of mouse glyoxalase I complexed with zopolrestat
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==Reference==
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<ref group="xtra">PMID:023857942</ref><references group="xtra"/><references/>
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[[Category: Lactoylglutathione lyase]]
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[[Category: Mus musculus]]
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[[Category: Chen, S.]]
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[[Category: Chen, Y.]]
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[[Category: Yuan, M.]]
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[[Category: Zhai, J.]]
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[[Category: Zhang, H.]]
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[[Category: Zhang, L.]]
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[[Category: Zhao, Y.]]
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[[Category: Lactoylglutachione lyase]]
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[[Category: Lyase-lyase inhibitor complex]]

Revision as of 20:54, 7 August 2013

Template:STRUCTURE 4kyh

Contents

Crystal structure of mouse glyoxalase I complexed with zopolrestat

Template:ABSTRACT PUBMED 23857942

Function

[LGUL_MOUSE] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity).

About this Structure

4kyh is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Zhai J, Zhang H, Zhang L, Zhao Y, Chen S, Chen Y, Peng X, Li Q, Yuan M, Hu X. Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis. ChemMedChem. 2013 Jul 15. doi: 10.1002/cmdc.201300243. PMID:23857942 doi:10.1002/cmdc.201300243

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OCA

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