2h6t

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[[Image:2h6t.jpg|left|200px]]<br /><applet load="2h6t" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2h6t.jpg|left|200px]]
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caption="2h6t, resolution 1.900&Aring;" />
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'''Secreted aspartic proteinase (Sap) 3 from Candida albicans complexed with pepstatin A'''<br />
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{{Structure
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|PDB= 2h6t |SIZE=350|CAPTION= <scene name='initialview01'>2h6t</scene>, resolution 1.900&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=IHN:3-HYDROXY-4-ISOBUTYL-4-[AMINOCARBONYLETHYL(AMINO CARBONYL-2-HYDROXY-5-METHYLHEXYL)TRI(AMINOCARBONYL ISOBUTYL)]BUTANOIC ACID'>IHN</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24]
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|GENE= SAP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5476 Candida albicans])
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}}
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'''Secreted aspartic proteinase (Sap) 3 from Candida albicans complexed with pepstatin A'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2H6T is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=IHN:'>IHN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Candidapepsin Candidapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.24 3.4.23.24] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H6T OCA].
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2H6T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H6T OCA].
==Reference==
==Reference==
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The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A., Borelli C, Ruge E, Schaller M, Monod M, Korting HC, Huber R, Maskos K, Proteins. 2007 Aug 15;68(3):738-48. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17510964 17510964]
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The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A., Borelli C, Ruge E, Schaller M, Monod M, Korting HC, Huber R, Maskos K, Proteins. 2007 Aug 15;68(3):738-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17510964 17510964]
[[Category: Candida albicans]]
[[Category: Candida albicans]]
[[Category: Candidapepsin]]
[[Category: Candidapepsin]]
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[[Category: hydrolase]]
[[Category: hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:38:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:13:20 2008''

Revision as of 15:13, 20 March 2008

Image:2h6t.jpg


PDB ID 2h6t

Drag the structure with the mouse to rotate
, resolution 1.900Å
Ligands: and
Gene: SAP3 (Candida albicans)
Activity: Candidapepsin, with EC number 3.4.23.24
Coordinates: save as pdb, mmCIF, xml



Secreted aspartic proteinase (Sap) 3 from Candida albicans complexed with pepstatin A


Overview

The family of secreted aspartic proteinases (Sap) encoded by 10 SAP genes is an important virulence factor during Candida albicans (C. albicans) infections. Antagonists to Saps could be envisioned to help prevent or treat candidosis in immunocompromised patients. The knowledge of several Sap structures is crucial for inhibitor design; only the structure of Sap2 is known. We report the 1.9 and 2.2 A resolution X-ray crystal structures of Sap3 in a stable complex with pepstatin A and in the absence of an inhibitor, shedding further light on the enzyme inhibitor binding. Inhibitor binding causes active site closure by the movement of a flap segment. Comparison of the structures of Sap3 and Sap2 identifies elements responsible for the specificity of each isoenzyme.

About this Structure

2H6T is a Single protein structure of sequence from Candida albicans. Full crystallographic information is available from OCA.

Reference

The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A., Borelli C, Ruge E, Schaller M, Monod M, Korting HC, Huber R, Maskos K, Proteins. 2007 Aug 15;68(3):738-48. PMID:17510964

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