4jo8
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of the activating Ly49H receptor in complex with m157 (G1F strain)== | |
| - | + | <StructureSection load='4jo8' size='340' side='right' caption='[[4jo8]], [[Resolution|resolution]] 3.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4jo8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Murid_herpesvirus_1 Murid herpesvirus 1] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JO8 FirstGlance]. <br> | |
| - | ==Function== | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">m157 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10366 Murid herpesvirus 1]), Klra8, Ly-49h, Ly49-h, Ly49H ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jo8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jo8 RCSB], [http://www.ebi.ac.uk/pdbsum/4jo8 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/KLRA8_MOUSE KLRA8_MOUSE]] Receptor on natural killer (NK) cells for class I MHC. | [[http://www.uniprot.org/uniprot/KLRA8_MOUSE KLRA8_MOUSE]] Receptor on natural killer (NK) cells for class I MHC. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Activating and inhibitory receptors on natural killer (NK) cells have a crucial role in innate immunity, although the basis of the engagement of activating NK cell receptors is unclear. The activating receptor Ly49H confers resistance to infection with murine cytomegalovirus by binding to the 'immunoevasin' m157. We found that m157 bound to the helical stalk of Ly49H, whereby two m157 monomers engaged the Ly49H dimer. The helical stalks of Ly49H lay centrally across the m157 platform, whereas its lectin domain was not required for recognition. Instead, m157 targeted an 'aromatic peg motif' present in stalks of both activating and inhibitory receptors of the Ly49 family, and substitution of this motif abrogated binding. Furthermore, ligation of m157 to Ly49H or Ly49C resulted in intracellular signaling. Accordingly, m157 has evolved to 'tackle the legs' of a family of NK cell receptors. | ||
| - | + | Targeting of a natural killer cell receptor family by a viral immunoevasin.,Berry R, Ng N, Saunders PM, Vivian JP, Lin J, Deuss FA, Corbett AJ, Forbes CA, Widjaja JM, Sullivan LC, McAlister AD, Perugini MA, Call MJ, Scalzo AA, Degli-Esposti MA, Coudert JD, Beddoe T, Brooks AG, Rossjohn J Nat Immunol. 2013 May 12. doi: 10.1038/ni.2605. PMID:23666294<ref>PMID:23666294</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Murid herpesvirus 1]] | [[Category: Murid herpesvirus 1]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Beddoe, T | + | [[Category: Beddoe, T]] |
| - | [[Category: Berry, R | + | [[Category: Berry, R]] |
| - | [[Category: Brooks, A G | + | [[Category: Brooks, A G]] |
| - | [[Category: Call, M J | + | [[Category: Call, M J]] |
| - | [[Category: Corbett, A J | + | [[Category: Corbett, A J]] |
| - | [[Category: Coudert, J D | + | [[Category: Coudert, J D]] |
| - | [[Category: Degli-Esposti, M A | + | [[Category: Degli-Esposti, M A]] |
| - | [[Category: Deuss, F A | + | [[Category: Deuss, F A]] |
| - | [[Category: Forbes, C A | + | [[Category: Forbes, C A]] |
| - | [[Category: Lin, J | + | [[Category: Lin, J]] |
| - | [[Category: McAlister, A D | + | [[Category: McAlister, A D]] |
| - | [[Category: Ng, N | + | [[Category: Ng, N]] |
| - | [[Category: Perugini, M A | + | [[Category: Perugini, M A]] |
| - | [[Category: Rossjohn, J | + | [[Category: Rossjohn, J]] |
| - | [[Category: Saunders, P M | + | [[Category: Saunders, P M]] |
| - | [[Category: Scalzo, A A | + | [[Category: Scalzo, A A]] |
| - | [[Category: Sullivan, L C | + | [[Category: Sullivan, L C]] |
| - | [[Category: Vivian, J P | + | [[Category: Vivian, J P]] |
| - | [[Category: Widjaja, J M | + | [[Category: Widjaja, J M]] |
[[Category: C-type lectin-like domain]] | [[Category: C-type lectin-like domain]] | ||
[[Category: Immune system-viral protein complex]] | [[Category: Immune system-viral protein complex]] | ||
[[Category: Natural killer receptor]] | [[Category: Natural killer receptor]] | ||
[[Category: Viral immunoevasin]] | [[Category: Viral immunoevasin]] | ||
Revision as of 11:14, 25 December 2014
Crystal structure of the activating Ly49H receptor in complex with m157 (G1F strain)
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Categories: Murid herpesvirus 1 | Mus musculus | Beddoe, T | Berry, R | Brooks, A G | Call, M J | Corbett, A J | Coudert, J D | Degli-Esposti, M A | Deuss, F A | Forbes, C A | Lin, J | McAlister, A D | Ng, N | Perugini, M A | Rossjohn, J | Saunders, P M | Scalzo, A A | Sullivan, L C | Vivian, J P | Widjaja, J M | C-type lectin-like domain | Immune system-viral protein complex | Natural killer receptor | Viral immunoevasin
