This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4iml
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ==CrossFab binding to human Angiopoietin 2== | |
| - | === | + | <StructureSection load='4iml' size='340' side='right' caption='[[4iml]], [[Resolution|resolution]] 2.93Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4iml]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IML FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4imk|4imk]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iml OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iml RCSB], [http://www.ebi.ac.uk/pdbsum/4iml PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Bispecific antibodies are considered as a promising class of future biotherapeutic molecules. They comprise binding specificities for two different antigens, which may provide additive or synergistic modes of action. There is a wide variety of design alternatives for such bispecific antibodies, including the "CrossMab" format. CrossMabs contain a domain crossover in one of the antigen-binding (Fab) parts, together with the "knobs-and-holes" approach, to enforce the correct assembly of four different polypeptide chains into an IgG-like bispecific antibody. We determined the crystal structure of a hAng-2-binding Fab in its crossed and uncrossed form and show that CH1-CL-domain crossover does not induce significant perturbations of the structure and has no detectable influence on target binding. | ||
| - | + | Crystal structure of an anti-Ang2 CrossFab demonstrates complete structural and functional integrity of the variable domain.,Fenn S, Schiller CB, Griese JJ, Duerr H, Imhof-Jung S, Gassner C, Moelleken J, Regula JT, Schaefer W, Thomas M, Klein C, Hopfner KP, Kettenberger H PLoS One. 2013 Apr 17;8(4):e61953. doi: 10.1371/journal.pone.0061953. Print 2013. PMID:23613981<ref>PMID:23613981</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Fenn, S | + | [[Category: Fenn, S]] |
| - | [[Category: Griese, J | + | [[Category: Griese, J]] |
| - | [[Category: Hopfner, K P | + | [[Category: Hopfner, K P]] |
| - | [[Category: Kettenberger, H | + | [[Category: Kettenberger, H]] |
| - | [[Category: Schiller, C | + | [[Category: Schiller, C]] |
[[Category: Antigen binding]] | [[Category: Antigen binding]] | ||
[[Category: Crossfab]] | [[Category: Crossfab]] | ||
[[Category: Human angiopoietin 2]] | [[Category: Human angiopoietin 2]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
Revision as of 12:30, 21 December 2014
CrossFab binding to human Angiopoietin 2
| |||||||||||
