4bds
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | [[4bds]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4bds]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BDS OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:023679855</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:023679855</ref><references group="xtra"/><references/> | ||
[[Category: Cholinesterase]] | [[Category: Cholinesterase]] | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Carletti, E.]] | [[Category: Carletti, E.]] | ||
[[Category: Jean, L.]] | [[Category: Jean, L.]] | ||
Revision as of 04:54, 9 April 2014
Contents |
Human butyrylcholinesterase in complex with tacrine
Template:ABSTRACT PUBMED 23679855
Disease
[CHLE_HUMAN] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
Function
[CHLE_HUMAN] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.[1] [2]
About this Structure
4bds is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Nachon F, Carletti E, Ronco C, Trovaslet M, Nicolet Y, Jean L, Renard PY. Crystal Structures of Human Cholinesterases in Complex with Huprine W and Tacrine: Elements of Specificity for Anti-Alzheimer's Drugs Targeting Acetyl- and Butyrylcholinesterase. Biochem J. 2013 May 17. PMID:23679855 doi:10.1042/BJ20130013
- ↑ Chilukuri N, Duysen EG, Parikh K, diTargiani R, Doctor BP, Lockridge O, Saxena A. Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents. Mol Pharmacol. 2009 Sep;76(3):612-7. doi: 10.1124/mol.109.055665. Epub 2009 Jun, 19. PMID:19542320 doi:10.1124/mol.109.055665
- ↑ Amitay M, Shurki A. The structure of G117H mutant of butyrylcholinesterase: nerve agents scavenger. Proteins. 2009 Nov 1;77(2):370-7. doi: 10.1002/prot.22442. PMID:19452557 doi:10.1002/prot.22442
