2hac
From Proteopedia
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| - | [[Image:2hac.jpg|left|200px]] | + | [[Image:2hac.jpg|left|200px]] |
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| - | '''Structure of Zeta-Zeta Transmembrane Dimer''' | + | {{Structure |
| + | |PDB= 2hac |SIZE=350|CAPTION= <scene name='initialview01'>2hac</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= CD3Z, T3Z, TCRZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Structure of Zeta-Zeta Transmembrane Dimer''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==Disease== | ==Disease== | ||
| - | Known | + | Known disease associated with this structure: Immunodeficiency due to defect in CD3-zeta OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186780 186780]] |
==About this Structure== | ==About this Structure== | ||
| - | 2HAC is a [ | + | 2HAC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAC OCA]. |
==Reference== | ==Reference== | ||
| - | The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor., Call ME, Schnell JR, Xu C, Lutz RA, Chou JJ, Wucherpfennig KW, Cell. 2006 Oct 20;127(2):355-68. PMID:[http:// | + | The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor., Call ME, Schnell JR, Xu C, Lutz RA, Chou JJ, Wucherpfennig KW, Cell. 2006 Oct 20;127(2):355-68. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17055436 17055436] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:14:41 2008'' |
Revision as of 15:14, 20 March 2008
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| Gene: | CD3Z, T3Z, TCRZ (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of Zeta-Zeta Transmembrane Dimer
Contents |
Overview
The T cell receptor (TCR) alphabeta heterodimer communicates ligand binding to the cell interior via noncovalently associated CD3gammaepsilon, CD3deltaepsilon, and zetazeta dimers. While structures of extracellular components of the TCR-CD3 complex are known, the transmembrane (TM) domains that mediate assembly have eluded structural characterization. Incorporation of the zetazeta signaling module is known to require one basic TCRalpha and two zetazeta aspartic acid TM residues. We report the NMR structure of the zetazeta(TM) dimer, a left-handed coiled coil with substantial polar contacts. Mutagenesis experiments demonstrate that three polar positions are critical for zetazeta dimerization and assembly with TCR. The two aspartic acids create a single structural unit at the zetazeta interface stabilized by extensive hydrogen bonding, and there is evidence for a structural water molecule (or molecules) within close proximity. This structural unit, representing only the second transmembrane dimer interface solved to date, serves as a paradigm for the assembly of all modules involved in TCR signaling.
Disease
Known disease associated with this structure: Immunodeficiency due to defect in CD3-zeta OMIM:[186780]
About this Structure
2HAC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor., Call ME, Schnell JR, Xu C, Lutz RA, Chou JJ, Wucherpfennig KW, Cell. 2006 Oct 20;127(2):355-68. PMID:17055436
Page seeded by OCA on Thu Mar 20 17:14:41 2008
