2hdc

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[[Image:2hdc.gif|left|200px]]<br /><applet load="2hdc" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2hdc.gif|left|200px]]
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caption="2hdc" />
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'''STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX'''<br />
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{{Structure
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|PDB= 2hdc |SIZE=350|CAPTION= <scene name='initialview01'>2hdc</scene>
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= GENESIS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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}}
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'''STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2HDC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDC OCA].
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2HDC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDC OCA].
==Reference==
==Reference==
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Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex., Jin C, Marsden I, Chen X, Liao X, J Mol Biol. 1999 Jun 18;289(4):683-90. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10369754 10369754]
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Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex., Jin C, Marsden I, Chen X, Liao X, J Mol Biol. 1999 Jun 18;289(4):683-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10369754 10369754]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Liao, X.]]
[[Category: Liao, X.]]
[[Category: Marsden, I.]]
[[Category: Marsden, I.]]
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[[Category: dyanamics]]
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[[Category: dyanamic]]
[[Category: genesis]]
[[Category: genesis]]
[[Category: nmr]]
[[Category: nmr]]
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[[Category: winged helix protein]]
[[Category: winged helix protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:40:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:15:41 2008''

Revision as of 15:15, 20 March 2008

Image:2hdc.gif


PDB ID 2hdc

Drag the structure with the mouse to rotate
Gene: GENESIS (Rattus norvegicus)
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX


Overview

Genesis is an HNF-3/fkh homologous protein. By using multi-dimensional NMR techniques, we have obtained the solution structure and backbone dynamics of Genesis complexed with a 17 base-pair DNA. Our results indicate that both the local folding and dynamic properties of Genesis are perturbed when it binds to the DNA site. Our data show that a conserved flexible amino acid sequence (wing 1) makes dynamic contacts to DNA in the complex and a short helix is induced by Genesis-DNA interactions. Our data indicate that, unlike the HNF-3gamma/DNA complex, a magnesium ion is not required in forming the stable Genesis-DNA complex.

About this Structure

2HDC is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex., Jin C, Marsden I, Chen X, Liao X, J Mol Biol. 1999 Jun 18;289(4):683-90. PMID:10369754

Page seeded by OCA on Thu Mar 20 17:15:41 2008

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