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4fz5

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{{STRUCTURE_4fz5| PDB=4fz5 | SCENE= }}
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==Crystal Structure of Human TIRAP TIR-domain==
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===Crystal Structure of Human TIRAP TIR-domain===
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<StructureSection load='4fz5' size='340' side='right' caption='[[4fz5]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4fz5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FZ5 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/TIRAP_HUMAN TIRAP_HUMAN]] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.<ref>PMID:18292575</ref> <ref>PMID:19509286</ref>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TIRAP, MAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fz5 RCSB], [http://www.ebi.ac.uk/pdbsum/4fz5 PDBsum]</span></td></tr>
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==About this Structure==
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</table>
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[[4fz5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZ5 OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kim, S.]]
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[[Category: Kim, S]]
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[[Category: Park, S.]]
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[[Category: Park, S]]
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[[Category: Shoelson, S E.]]
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[[Category: Shoelson, S E]]
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[[Category: Woo, J R.]]
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[[Category: Woo, J R]]
[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Myd88]]
[[Category: Myd88]]
[[Category: Scaffold]]
[[Category: Scaffold]]
[[Category: Tirap]]
[[Category: Tirap]]

Revision as of 11:45, 21 December 2014

Crystal Structure of Human TIRAP TIR-domain

4fz5, resolution 3.60Å

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