4gh8
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_4gh8| PDB=4gh8 | SCENE= }} | {{STRUCTURE_4gh8| PDB=4gh8 | SCENE= }} | ||
===Crystal structure of a 'humanized' E. coli dihydrofolate reductase=== | ===Crystal structure of a 'humanized' E. coli dihydrofolate reductase=== | ||
| + | {{ABSTRACT_PUBMED_23733948}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4gh8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GH8 OCA]. | [[4gh8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GH8 OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023733948</ref><references group="xtra"/><references/> | ||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Escherichia coli k-12]] | [[Category: Escherichia coli k-12]] | ||
Revision as of 12:30, 3 July 2013
Contents |
Crystal structure of a 'humanized' E. coli dihydrofolate reductase
Template:ABSTRACT PUBMED 23733948
Function
[DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
About this Structure
4gh8 is a 2 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.
Reference
- Liu CT, Hanoian P, French JB, Pringle TH, Hammes-Schiffer S, Benkovic SJ. Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10159-64. doi:, 10.1073/pnas.1307130110. Epub 2013 Jun 3. PMID:23733948 doi:10.1073/pnas.1307130110
