3w1o
From Proteopedia
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| - | + | ==Neisseria DNA mimic protein DMP12== | |
| - | ===Neisseria | + | <StructureSection load='3w1o' size='340' side='right' caption='[[3w1o]], [[Resolution|resolution]] 1.85Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3w1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis_mc58 Neisseria meningitidis mc58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W1O FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NMB2123 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=122586 Neisseria meningitidis MC58])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w1o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w1o RCSB], [http://www.ebi.ac.uk/pdbsum/3w1o PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | DNA mimic proteins are unique factors that control the DNA-binding activity of target proteins by directly occupying their DNA-binding sites. To date, only a few DNA mimic proteins have been reported and their functions analyzed. Here, we present evidence that the Neisseria conserved hypothetical protein DMP12 should be added to this list. Our gel filtration and analytical ultracentrifugation results showed that the DMP12 monomer interacts with the dimeric form of the bacterial histone-like protein HU. Subsequent structural analysis of DMP12 showed that the shape and electrostatic surface of the DMP12 monomer are similar to those of the straight portion of the bent HU-bound DNA and complementary to those of HU protein dimer. DMP12 also protects HU protein from limited digestion by trypsin and enhances the growth rate Escherichia coli. Functionally, HU proteins participate in bacterial nucleoid formation, as well as recombination, gene regulation and DNA replication. The interaction between DMP12 and HU protein might, therefore, play important roles in these DNA-related mechanisms. | ||
| - | + | Neisseria conserved hypothetical protein DMP12 is a DNA mimic that binds to histone-like HU protein.,Wang HC, Wu ML, Ko TP, Wang AH Nucleic Acids Res. 2013 Mar 26. PMID:23531546<ref>PMID:23531546</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Neisseria meningitidis mc58]] | [[Category: Neisseria meningitidis mc58]] | ||
| - | [[Category: Ko, T P | + | [[Category: Ko, T P]] |
| - | [[Category: Wang, A H.J | + | [[Category: Wang, A H.J]] |
| - | [[Category: Wang, H C | + | [[Category: Wang, H C]] |
| - | [[Category: Wu, M L | + | [[Category: Wu, M L]] |
[[Category: Dna mimic]] | [[Category: Dna mimic]] | ||
[[Category: Hu protein]] | [[Category: Hu protein]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
Revision as of 10:19, 4 January 2015
Neisseria DNA mimic protein DMP12
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