3w6j
From Proteopedia
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| - | + | ==Crystal structure of ScpAB core complex== | |
| - | === | + | <StructureSection load='3w6j' size='340' side='right' caption='[[3w6j]], [[Resolution|resolution]] 2.60Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3w6j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W6J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W6J FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3w6k|3w6k]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">scpA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Geobacillus stearothermophilus]), scpB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Geobacillus stearothermophilus])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w6j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w6j RCSB], [http://www.ebi.ac.uk/pdbsum/3w6j PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | In many bacteria, a homodimer of structural-maintenance-of-chromosomes proteins associates with two regulatory subunits (known as ScpA and ScpB), assembling a protein complex that plays a crucial role in chromosome organization and segregation. It remains poorly understood, however, how this complex might work at the mechanistic level. Here, we report crystal structures of the ScpAB core complex that display a highly unusual structure in which the central segment of ScpA winds around an asymmetrically oriented ScpB dimer. The two C-terminal domains of the ScpB dimer primarily interact with different regions of ScpA with different affinities. Moreover, flexible interdomain regions of ScpB contribute to a dynamic folding process of the ScpAB subcomplex. Together with other genetic and biochemical assays, we provide evidence that internal structural changes of the ScpAB subcomplex are tightly coupled with activation of the structural-maintenance-of-chromosomes ATPase. | ||
| - | + | Molecular Basis of SMC ATPase Activation: Role of Internal Structural Changes of the Regulatory Subcomplex ScpAB.,Kamada K, Miyata M, Hirano T Structure. 2013 Mar 26. pii: S0969-2126(13)00057-9. doi:, 10.1016/j.str.2013.02.016. PMID:23541893<ref>PMID:23541893</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Geobacillus stearothermophilus]] | [[Category: Geobacillus stearothermophilus]] | ||
| - | [[Category: Hirano, T | + | [[Category: Hirano, T]] |
| - | [[Category: Kamada, K | + | [[Category: Kamada, K]] |
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Regulatory subcomplex]] | [[Category: Regulatory subcomplex]] | ||
[[Category: Smc]] | [[Category: Smc]] | ||
[[Category: Winged hth]] | [[Category: Winged hth]] | ||
Revision as of 07:07, 21 December 2014
Crystal structure of ScpAB core complex
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