2lu4

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{{STRUCTURE_2lu4| PDB=2lu4 | SCENE= }}
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==Solution NMR structure of the beta2 carbohydrate module of AMP-activated protein kinase bound to glucosyl-cyclodextrin==
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===Solution NMR structure of the beta2 carbohydrate module of AMP-activated protein kinase bound to glucosyl-cyclodextrin===
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<StructureSection load='2lu4' size='340' side='right' caption='[[2lu4]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lu4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LU4 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2lu3|2lu3]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Prkab2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lu4 RCSB], [http://www.ebi.ac.uk/pdbsum/2lu4 PDBsum]</span></td></tr>
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</table>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/AAKB2_RAT AAKB2_RAT]] Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity).
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*[[AMP-activated protein kinase|AMP-activated protein kinase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[2lu4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU4 OCA].
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Gooley, P.]]
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[[Category: Gooley, P]]
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[[Category: Koay, A.]]
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[[Category: Koay, A]]
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[[Category: Stapleton, D.]]
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[[Category: Stapleton, D]]
[[Category: Carbohydrate binding module]]
[[Category: Carbohydrate binding module]]
[[Category: Glycogen binding]]
[[Category: Glycogen binding]]
[[Category: Sugar binding protein]]
[[Category: Sugar binding protein]]

Revision as of 11:35, 18 December 2014

Solution NMR structure of the beta2 carbohydrate module of AMP-activated protein kinase bound to glucosyl-cyclodextrin

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