4au7

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{{STRUCTURE_4au7| PDB=4au7 | SCENE= }}
{{STRUCTURE_4au7| PDB=4au7 | SCENE= }}
===The structure of the Suv4-20h2 ternary complex with histone H4===
===The structure of the Suv4-20h2 ternary complex with histone H4===
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{{ABSTRACT_PUBMED_24049080}}
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==Function==
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[[http://www.uniprot.org/uniprot/SV422_MOUSE SV422_MOUSE]] Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).<ref>PMID:15145825</ref>
==About this Structure==
==About this Structure==
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[[4au7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AU7 OCA].
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[[4au7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AU7 OCA].
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==See Also==
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*[[Histone methyltransferase|Histone methyltransferase]]
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==Reference==
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<ref group="xtra">PMID:024049080</ref><references group="xtra"/><references/>
[[Category: Histone-lysine N-methyltransferase]]
[[Category: Histone-lysine N-methyltransferase]]
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[[Category: Mus musculus]]
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[[Category: Lk3 transgenic mice]]
[[Category: Cronin, N B.]]
[[Category: Cronin, N B.]]
[[Category: Southall, S M.]]
[[Category: Southall, S M.]]

Revision as of 06:51, 15 January 2014

Template:STRUCTURE 4au7

Contents

The structure of the Suv4-20h2 ternary complex with histone H4

Template:ABSTRACT PUBMED 24049080

Function

[SV422_MOUSE] Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).[1]

About this Structure

4au7 is a 3 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.

See Also

Reference

  • Southall SM, Cronin NB, Wilson JR. A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases. Nucleic Acids Res. 2013 Sep 18. PMID:24049080 doi:10.1093/nar/gkt776
  1. ↑ Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D, Jenuwein T. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev. 2004 Jun 1;18(11):1251-62. Epub 2004 May 14. PMID:15145825 doi:http://dx.doi.org/10.1101/gad.300704

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