4bjr
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of the complex between Prokaryotic Ubiquitin-like Protein Pup and its Ligase PafA== | |
| - | + | <StructureSection load='4bjr' size='340' side='right' caption='[[4bjr]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4bjr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BJR FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bjr RCSB], [http://www.ebi.ac.uk/pdbsum/4bjr PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Prokaryotic ubiquitin-like protein (Pup) is covalently attached to target proteins by the ligase PafA, tagging substrates for proteasomal degradation. The crystal structure of Pup in complex with PafA, reported here, reveals that a long groove wrapping around the enzyme serves as a docking site for Pup. Upon binding, the C-terminal region of the intrinsically disordered Pup becomes ordered to form two helices connected by a linker, positioning the C-terminal glutamate in the active site of PafA. | ||
| - | + | Crystal Structure of the Complex between Prokaryotic Ubiquitin-like Protein and Its Ligase PafA.,Barandun J, Delley CL, Ban N, Weber-Ban E J Am Chem Soc. 2013 Apr 23. PMID:23601177<ref>PMID:23601177</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Corynebacterium glutamicum]] | [[Category: Corynebacterium glutamicum]] | ||
| - | [[Category: Ban, N | + | [[Category: Ban, N]] |
| - | [[Category: Barandun, J | + | [[Category: Barandun, J]] |
| - | [[Category: Delley, C L | + | [[Category: Delley, C L]] |
| - | [[Category: Weber-Ban, E | + | [[Category: Weber-Ban, E]] |
[[Category: Ligase]] | [[Category: Ligase]] | ||
[[Category: Prokaryotic proteasome]] | [[Category: Prokaryotic proteasome]] | ||
Revision as of 09:56, 21 December 2014
Crystal structure of the complex between Prokaryotic Ubiquitin-like Protein Pup and its Ligase PafA
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