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4br3

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{{STRUCTURE_4br3| PDB=4br3 | SCENE= }}
{{STRUCTURE_4br3| PDB=4br3 | SCENE= }}
===Determination of potential scaffolds for human choline kinase alpha 1 by chemical deconvolution studies===
===Determination of potential scaffolds for human choline kinase alpha 1 by chemical deconvolution studies===
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{{ABSTRACT_PUBMED_23813777}}
==Function==
==Function==
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==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:023813777</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Entrena, A.]]
[[Category: Entrena, A.]]

Revision as of 04:26, 18 July 2013

Template:STRUCTURE 4br3

Contents

Determination of potential scaffolds for human choline kinase alpha 1 by chemical deconvolution studies

Template:ABSTRACT PUBMED 23813777

Function

[CHKA_HUMAN] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.[1]

About this Structure

4br3 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Sahun-Roncero M, Rubio-Ruiz B, Conejo-Garcia A, Velazquez-Campoy A, Entrena A, Hurtado-Guerrero R. Determination of Potential Scaffolds for Human Choline Kinase alpha1 by Chemical Deconvolution Studies. Chembiochem. 2013 Jun 28. doi: 10.1002/cbic.201300195. PMID:23813777 doi:10.1002/cbic.201300195
  1. ↑ Gallego-Ortega D, Ramirez de Molina A, Ramos MA, Valdes-Mora F, Barderas MG, Sarmentero-Estrada J, Lacal JC. Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment. PLoS One. 2009 Nov 12;4(11):e7819. doi: 10.1371/journal.pone.0007819. PMID:19915674 doi:10.1371/journal.pone.0007819

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OCA

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