4e3c

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{{STRUCTURE_4e3c| PDB=4e3c | SCENE= }}
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==X-ray crystal structure of human IKK2 in an active conformation==
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===X-ray crystal structure of human IKK2 in an active conformation===
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<StructureSection load='4e3c' size='340' side='right' caption='[[4e3c]], [[Resolution|resolution]] 3.98&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4e3c]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E3C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E3C FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/IKKB_HUMAN IKKB_HUMAN]] Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.<ref>PMID:11297557</ref> <ref>PMID:17213322</ref> <ref>PMID:20434986</ref> <ref>PMID:20410276</ref> <ref>PMID:20797629</ref> <ref>PMID:21138416</ref>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IKBKB, IKKB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/I-kappa-B_kinase I-kappa-B kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.10 2.7.11.10] </span></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e3c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e3c RCSB], [http://www.ebi.ac.uk/pdbsum/4e3c PDBsum]</span></td></tr>
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[[4e3c]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E3C OCA].
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</table>
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__TOC__
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==Reference==
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</StructureSection>
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: I-kappa-B kinase]]
[[Category: I-kappa-B kinase]]
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[[Category: Ghosh, G.]]
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[[Category: Ghosh, G]]
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[[Category: Hauenstein, A V.]]
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[[Category: Hauenstein, A V]]
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[[Category: Huang, D B.]]
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[[Category: Huang, D B]]
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[[Category: Huxford, T.]]
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[[Category: Huxford, T]]
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[[Category: Polley, S.]]
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[[Category: Polley, S]]
[[Category: Auto-phosphorylation]]
[[Category: Auto-phosphorylation]]
[[Category: Kanase]]
[[Category: Kanase]]
[[Category: Nemo binding]]
[[Category: Nemo binding]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 10:50, 21 December 2014

X-ray crystal structure of human IKK2 in an active conformation

4e3c, resolution 3.98Å

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