4g59
From Proteopedia
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| - | + | ==Crystal structure of the murine cytomegalovirus MHC-I homolog m152 with ligand RAE-1 gamma== | |
| - | + | <StructureSection load='4g59' size='340' side='right' caption='[[4g59]], [[Resolution|resolution]] 2.44Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4g59]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Murid_herpesvirus_1 Murid herpesvirus 1] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G59 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Raet1c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), m152 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10366 Murid herpesvirus 1])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g59 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g59 RCSB], [http://www.ebi.ac.uk/pdbsum/4g59 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Natural killer (NK) cells are activated by engagement of the NKG2D receptor with ligands on target cells stressed by infection or tumorigenesis. Several human and rodent cytomegalovirus (CMV) immunoevasins down-regulate surface expression of NKG2D ligands. The mouse CMV MHC class I (MHC-I)-like m152/gp40 glycoprotein down-regulates retinoic acid early inducible-1 (RAE1) NKG2D ligands as well as host MHC-I. Here we describe the crystal structure of an m152/RAE1gamma complex and confirm the intermolecular contacts by mutagenesis. m152 interacts in a pincer-like manner with two sites on the alpha1 and alpha2 helices of RAE1 reminiscent of the NKG2D interaction with RAE1. This structure of an MHC-I-like immunoevasin/MHC-I-like ligand complex explains the binding specificity of m152 for RAE1 and allows modeling of the interaction of m152 with classical MHC-I and of related viral immunoevasins. | ||
| - | + | Structural basis of mouse cytomegalovirus m152/gp40 interaction with RAE1gamma reveals a paradigm for MHC/MHC interaction in immune evasion.,Wang R, Natarajan K, Revilleza MJ, Boyd LF, Zhi L, Zhao H, Robinson H, Margulies DH Proc Natl Acad Sci U S A. 2012 Nov 19. PMID:23169621<ref>PMID:23169621</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Murid herpesvirus 1]] | [[Category: Murid herpesvirus 1]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Margulies, D H | + | [[Category: Margulies, D H]] |
| - | [[Category: Natarajan, K | + | [[Category: Natarajan, K]] |
| - | [[Category: Wang, R | + | [[Category: Wang, R]] |
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Immunoevasion]] | [[Category: Immunoevasion]] | ||
[[Category: Mhc-i fold]] | [[Category: Mhc-i fold]] | ||
[[Category: Stress induced ligand]] | [[Category: Stress induced ligand]] | ||
Revision as of 10:58, 21 December 2014
Crystal structure of the murine cytomegalovirus MHC-I homolog m152 with ligand RAE-1 gamma
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