2hr9
From Proteopedia
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| - | [[Image:2hr9.gif|left|200px]] | + | [[Image:2hr9.gif|left|200px]] |
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| - | '''Solution structure of human translationally controlled tumor protein''' | + | {{Structure |
| + | |PDB= 2hr9 |SIZE=350|CAPTION= <scene name='initialview01'>2hr9</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= TPT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Solution structure of human translationally controlled tumor protein''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2HR9 is a [ | + | 2HR9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1Y41. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HR9 OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure and mapping of a very weak calcium-binding site of human translationally controlled tumor protein by NMR., Feng Y, Liu D, Yao H, Wang J, Arch Biochem Biophys. 2007 Nov 1;467(1):48-57. Epub 2007 Aug 30. PMID:[http:// | + | Solution structure and mapping of a very weak calcium-binding site of human translationally controlled tumor protein by NMR., Feng Y, Liu D, Yao H, Wang J, Arch Biochem Biophys. 2007 Nov 1;467(1):48-57. Epub 2007 Aug 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17897616 17897616] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: tumor protein]] | [[Category: tumor protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:20:32 2008'' |
Revision as of 15:20, 20 March 2008
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| Gene: | TPT1 (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of human translationally controlled tumor protein
Overview
Human translationally controlled tumor protein (TCTP) is a growth-related, calcium-binding protein. We determined the solution structure and backbone dynamics of human TCTP, and identified the calcium-binding site of human TCTP using multi-dimensional NMR spectroscopy. The overall structure of human TCTP has a rather rigid well-folded core and a very flexible long loop connected by a short two-strand beta-sheet, which shows a conserved fold in the TCTP family. The C-terminal portions of loop L(alpha3beta8) and strand beta9 and the N-terminal region of strand beta8 may form a calcium-binding site in the human TCTP structure, which is largely conserved in the sequence alignment of TCTPs. The K(d) value for the calcium binding is 0.022-0.025 M indicating a very weak calcium-binding site.
About this Structure
2HR9 is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1Y41. Full crystallographic information is available from OCA.
Reference
Solution structure and mapping of a very weak calcium-binding site of human translationally controlled tumor protein by NMR., Feng Y, Liu D, Yao H, Wang J, Arch Biochem Biophys. 2007 Nov 1;467(1):48-57. Epub 2007 Aug 30. PMID:17897616
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