Glutathione S-transferase

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Revision as of 08:58, 12 March 2014

Glutathione S-transferase (GST) catalyzes the conjugation of reduced glutathione (GSH) to a variety of exogenous and endogenous hydrophobic electrophiles. For example, GST can detoxify peroxidised lipids. All eukaryotes possess a variety of GSTs with catalytic and non-catalytic activities. GST is divided into classes: α, δ, ε, κ, μ, ν, ω, π, ρ, σ (hematopoietic prostaglandin D synthase), τ, χ, ϑ, ζ and microsomal.

3D structures of glutathione S-transferase

Updated on 12-March-2014

GST

4hz4 – GST – Actinobacillus pleuropneumoniae
1gsb, 1gsc – rGST – rat
3ubk – LiGST – Leptospira interrogans
3uap - McGST – Methylococcus capsulatus
1aw9 - cGST III – corn
1okt – PfGST – Plasmodium falciparum
3fr6 - PfGST (mutant)
1tw9 – GST - Heligmosomoides polygyrus
1yq1 - CeGST – Caenorhabditis elegans
1y6e - SjGST – Schistosoma japonicum
2fno, 3lq7 - AtGST – Agrobacterium tumefaciens
2on7 – NaGST-1 – Necator americanus
3erf - yGST II – yeast
3f6f – DmGST – Drosophila melanogaster
3lxt - PsfGST – Pseudomonas fluorescens
4eci - PaGST – Pseudomonas aeruginosa
3niv - GST – Legionella pneumophila
3tot - RsGST – Ralstonia solanacearum
3ay8, 4e8e - siGST – silkworm
1jlw - AcGST - Anopheles cracens
4f03 - PcGST - Phanerochaete chrysosporium
3vwx – GST 6B (mutant) – fly
3w8s – GST 3 – hookworm
4j2f – GST – castor bean
4mp4 – GST – Acinetobacter baumannii
4o7h – GST – Rhodospirillum rubrum
4o92 – GST – Pichia kudriavzevii

GST binary complex with GSH

2x64 – GST + GSH – Xylella fastidiosa
4hz2 - GST + GSH - Xanthobacter autotrophicus
4ecj - PaGST + GSH
1fhe, 2fhe - FhGST + GSH – Fasciola hepatica
1pmt, 2pmt - GST + GSH – Proteus mirabilis
1m0u, 3gh6 - DmGST + GSH
1oe7, 1oe8 - ShGST + GSH – Schistosoma haematobium
1u3i - GST + GSH - Schistosoma mansoni
1oyj - GST + GSH - rice
1u87, 1gne - SjGST + GSH
2dsa, 2gdr - GST + GSH – Burkholderia xenovorans
4isd - GST + GSH – Burkholderia glumae
2on5 – NaGST-2 + GSH
2nto - OaGST + GSH – Ochrobactrum anthropi
2pvq - OaGST (mutant) + GSH
3ibh - yGST II + GSH
3fr9 - PfGST + GSH
3m3m - PsfGST + GSH
3lsz - GST + GSH – Rhodobacter sphaeroides
3n5o - GST + GSH – Coccidioides immitis
3tou, 4kf9 - RsGST + GSH
3uar - McGST + GSH
4g9h, 4gci - GST + GSH – Yersinia pestis
4gf0 - GST + GSH - Sulfitobacter
1jlv - AcGST + GSH
4g19 - PcGST + GSH
4ikh – GST + GSH – Pseudomonas protegens
4jed – GST + GSH – Methylobacter radiotolerans
4kgi – GST + GSH – Shigella flexneri
4kh7 – GST + GSH – Salmonella enterica
4mk3 – GST + GSH derivative – Cupriavidus metallidurans
4nhw – GST + GSH – Sinorhizobium meliloti

GST binary complex

3ubl - LiGST + GSH derivative
2gsq – sqGST + GSH derivative – squid
2gst, 3gst, 4gst, 5gst, 1gss - rGST + GSH derivative
1gnw - AtGST + GSH derivative – Arabidopsis thaliana
1aqv - hGST + GSH derivative – human
1gtb, 1gta - SjGST + praziquantel
1m99, 1m9a, 1m9b - SjGST + GSH derivative
1q4j, 2aaw, 3frc - PfGST + GSH derivative
3fr3 - PfGST (mutant) + GSH derivative
1bx9 - AtGST + herbicide
1bye - cGST I + herbicide
1axd – cGST I + lactoyl-GSH
1a0f, 1n2a - GST + GSH derivative – Eschericia coli
1f2e - GST + GSH derivative – Sphingomonas paucimobilis
1mtc - rGST + GSH derivative
1ua5 - SjGST + GSH derivative
1u88 - SjGST (mutant) + GSH derivative
3erg - yGST II + GSH derivative
3qmz - yGST + dynein heavy chain
2ycd - AtGST + GSH derivative

GST α class

1guh, 1gsd, 1k3o, 1pkz – hGST A1-1
1xwg, 3q74, 3u6v, 3zfb, 3zfl - hGST A1-1 (mutant)
1gum - hGST A4-4
1guk - mGST A4-4 – mouse
1vf4 - GgGST A1-1 - chicken

GST α class complex with GSH

1pkw - hGST + GSH
1usb - hGST (mutant) + GSH
1f3a - mGST A1-1+ GSH
3i69, 3i6a - hGST A1-1 (mutant)+ GSH
2wju - hGST A2-2 + GSH
4acs - hGST A2-2 (mutant) + GSH
1tdi - hGST A3-3 + GSH
1vf1 - GgGST A1-1 + GSH

GST α class complex

1gsf – hGST A1-1 + ethacrynic acid
1ags, 1pl2, 1ydk, 2r3x, 2r6k, 3ktl, 3l0h – hGST (mutant) + GSH derivative
1k3l, 1k3y, 1pl1 - hGST + GSH derivative
1gse – hGST (mutant) + GSH + ethacrynic acid
3ik9 - hGST A1-1 + GSDN
4hj2 - hGST A1-1 + chemotherapeutic drug
2vct - hGST A2-2 + steroid
2vcv - hGST A3-3 + steroid
1gul - hGST A4-4+ iodobenzyl-GSH
3ik7 - hGST A4-4 + GSDHN
1b48 - mGST A4-4 + GSH derivative
1f3b - mGST A1-1 + GSH derivative
1ml6 - mGST A2-2+ GSH derivative
1ev4, 1ev9 - rGST A1-1 (mutant) + GSH derivative
1vf2, 1vf3 – GgGST A1-1 + GSH derivative

GST δ class

1r5a, 1v2a, 1pn9 - AcGST + GSH derivative
3f63, 3g7i - AdGST + GSH derivative - Anopheles dirus
3f6d, 3g7j - AdGST )mutant) + GSH derivative
3ein - DmGST + GSH
3vk9 - siGST
4i97 – GST + GSH – Scaptomyza nigrita

GST ε class

2il3 - AgGST – Anopheles gambiae
2imi - AgGST + GSH
2imk - AgGST + GSH derivative

GST κ class

3rpp - hGST
1r4w - rGST + GSH derivative
1yzx, 3rpn - hGST + GSH derivative

GST μ class

1gsb, 1gsc – rGST
6gsu, 6gsv, 6gsw, 6gsx, 6gsy, 5fwg, 3fyg - rGST (mutant)
1gtu, 2gtu, 3gtu, 4gtu - hGST
2dc5 - mGST
2wrt - FhGST

GST μ class complex with GSH

1xw5, 1xw6 - hGST + GSH
2f8f - mGST (mutant) + GSH
3crt - SjGST + GSH
3cru, 3d0z - SjGST (mutant) + GSH
6gst - rGST + GSH

GST μ class complex

1gst - GgGST + GSH derivative
1c72 - GgGST + conjugate
1hna, 1hnb, 1hnc, 1xwk, 1ykc, 1yj6, 2ab6, 2f3m – hGST + GSH derivative
2c4j - hGST (mutant) + GSH derivative
1b4p - rGST + GSH derivative
3gur - hGST + GSH + drug
3gus - hGST + drug
1gsu - cGST + GSH derivative
4ai6, 4akg – SjGST + ATP + ADP
4aki – SjGST + ATP
4akh – SjGST + AMPPNP

GST ν class

2ws2 - GST – Haemonchus contortus
4mzw – GST + GSH derivative – Streptococcus sanguinis

GST π class

1bay - mGST
10gs, 14gs, 16gs, 1lbk - hGST
22gs, 1eog, 1eoh, 3hjm, 3hkr, 3kmn - hGST (mutant)
4ecb, 4ecc – SjGST/hKininogen peptide

GST π class complex with GSH

1gsy - mGST + GSH
1tu7, 2hnl - OvGST + GSH - Onchocerca volvulus
5gss, 6gss, 7gss, 8gss, 19gs, 3dd3 - hGST + GSH
1md3, 1md4, 1px6, 1px7, 1kbn - hGST (mutant) + GSH
3t2u - GST + GSH – Wuchereria bancrofti

GST π class complex

1gss – rGST + GSH derivative
1tu8 - OvGST + GSH derivative
1glq, 1glp, 2glr, 1gti - mGST + GSH derivative
2oac, 2oad, 2oa7, 3o76 - mGST (mutant) + GSH derivative
2gss, 3dgq – hGST + ethacrynic acid
3n9j - hGST + ethacrynic acid derivative
3gss, 11gs – hGST + ethacrynic acid + GSH
3hjo, 3km6, 3kmo - hGST (mutant) + ethacrynic acid + GSH
1pgt, 2pgt, 4gss, 17gs, 2j9h, 3csi - hGST (mutant) + GSH derivative
1aqw, 1aqx, 9gss, 12gs, 18gs, 3pgt, 4pgt, 1zgn, 2a2r, 2a2s, 3csh - hGST + GSH derivative
20gs - hGST + cibacron blue
13gs, 3csj - hGST + drug
3ie3 - hGST (mutant) + drug
2gsr - GST + GSH derivative - pig

GST ρ class

3qav - AcGST – Atlantic clam
3qaw - AcGST + GSH

GST σ class

2c8u, 2cai - ShGST (mutant)
3vpt, 4e8h – siGST
2ca8 - ShGST + GSH
2wb9 - FhGST + GSH
2wdu - FhGST + GSH + GSH derivative
1zl9 - CeGST + GSH
4ec0, 4edz, 4ee0, 4edy, 1iyh, 1iyi, 2vcq, 2vcw, 2vcx, 2vcz, 2vd0, 2vd1 - hGST + GSH
3vi7 - hGST (mutant) + GSH
1v40, 2cvd, 3ee2, 3kxo - hGST + GSH + inhibitor
3vi5, 3vi7 - hGST (mutant) + GSH + inhibitor
2caq - ShGST (mutant) + GSH
1pd2 - rGST + GSH
2c80 - ShGST + GSH derivative
1gsq - sqGST + GSH derivative
3vpq – siGST + GSH
3vur – siGST + GSH derivative

GST ϑ class

2ljr, 2c3n, 4mpf - hGST
2c3t - hGST (mutant)
1ljr, 4mpg - hGST + GSH
3mak - DmGST + GSH
3ljr - hGST + GSH derivative
2c3q - hGST (mutant) + GSH derivative

GST χ class

3ppu - PcGST + GSH

GST ω class

1eem – hGST
3q18, 3vln, 4is0 - hGST (mutant)
3rbt - siGST
3lfl - hGST + GSH
3qag, 3q19 - hGST (mutant) + GSH

GST ζ class

1e6b – AtGST
2cz3 - mGST
2cz2 - mGST + GSH
1fw1 - hGST + GSH

GST τ class

1gwc - GST – wheat
2vo4 - sGST + GSH derivative – soybean
3fhs - sGST + GSH

Microsomal GST

2h8a - rGST + GSH

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Glutathione_S-transferase"

Category: Topic Page

@@ Line 12: / Line 12: @@
 [[1gsb]], [[1gsc]] – rGST – rat<br />
 [[3ubk]] – LiGST – ''Leptospira interrogans''<br />
-[[3uap]] - GST – ''Methylococcus capsulatus''<br />
+[[3uap]] - McGST – ''Methylococcus capsulatus''<br />
 [[1aw9]] - cGST III – corn<br />
 [[1okt]] – PfGST – ''Plasmodium falciparum''<br />
@@ Line 27: / Line 27: @@
 [[3niv]] - GST – ''Legionella pneumophila''<br />
 [[3tot]] - RsGST – ''Ralstonia solanacearum''<br />
-[[3ay8]] - siGST – silkworm<br />
+[[3ay8]], [[4e8e]] - siGST – silkworm<br />
 [[1jlw]] - AcGST - ''Anopheles cracens''<br />
-[[4f03]] - PcGST - ''Phanerochaete chrysosporium''
+[[4f03]] - PcGST - ''Phanerochaete chrysosporium''<br />
+[[3vwx]] – GST 6B (mutant) – fly<br />
+[[3w8s]] – GST 3 – hookworm<br />
+[[4j2f]] – GST – castor bean<br />
+[[4mp4]] – GST – ''Acinetobacter baumannii''<br />
+[[4o7h]] – GST – ''Rhodospirillum rubrum''<br />
+[[4o92]] – GST – ''Pichia kudriavzevii''<br />
 ===GST binary complex with GSH===
@@ Line 44: / Line 50: @@
 [[1u87]], [[1gne]] - SjGST + GSH<BR />
 [[2dsa]], [[2gdr]] - GST + GSH – ''Burkholderia xenovorans''<br />
+[[4isd]] - GST + GSH – ''Burkholderia glumae''<br />
 [[2on5]] – NaGST-2 + GSH<BR />
 [[2nto]] - OaGST + GSH – ''Ochrobactrum anthropi''<br />
@@ Line 52: / Line 59: @@
 [[3lsz]] - GST + GSH – ''Rhodobacter  sphaeroides''<br />
 [[3n5o]] - GST + GSH – ''Coccidioides immitis''<br />
-[[3tou]] - RsGST + GSH<BR />
+[[3tou]], [[4kf9]] - RsGST + GSH<BR />
 [[3uar]] - McGST + GSH<BR />
 [[4g9h]], [[4gci]] - GST + GSH – ''Yersinia pestis''<br />
 [[4gf0]] - GST + GSH - ''Sulfitobacter''<br />
 [[1jlv]] - AcGST + GSH<br />
-[[4g19]] - PcGST + GSH
+[[4g19]] - PcGST + GSH<br />
+[[4ikh]] – GST + GSH – ''Pseudomonas protegens''<br />
+[[4jed]] – GST + GSH – ''Methylobacter radiotolerans''<br />
+[[4kgi]] – GST + GSH – ''Shigella flexneri''<br />
+[[4kh7]] – GST + GSH – ''Salmonella enterica''<br />
+[[4mk3]] – GST + GSH derivative – ''Cupriavidus metallidurans''<br />
+[[4nhw]] – GST + GSH – ''Sinorhizobium meliloti''<br />
 ===GST binary complex===
@@ Line 108: / Line 121: @@
 [[1gse]] – hGST (mutant) + GSH + ethacrynic acid<br />
 [[3ik9]] - hGST A1-1 + GSDN<br />
+[[4hj2]] - hGST A1-1 + chemotherapeutic drug<br />
 [[2vct]] - hGST A2-2 + steroid<br />
 [[2vcv]] - hGST A3-3 + steroid<br />
@@ Line 124: / Line 138: @@
 [[3f6d]], [[3g7j]] - AdGST )mutant) + GSH derivative<br />
 [[3ein]] - DmGST + GSH<BR />
-[[3vk9]] - siGST
+[[3vk9]] - siGST <br />
+[[4i97]] – GST + GSH – ''Scaptomyza nigrita''<br />
 ===GST ε class===
@@ Line 170: / Line 185: @@
 ===GST ν class===
-[[2ws2]] - GST – ''Haemonchus contortus''
+[[2ws2]] - GST – ''Haemonchus contortus''<br />
+[[4mzw]] – GST + GSH derivative – ''Streptococcus sanguinis''<br />
 ===GST π class===
@@ Line 212: / Line 228: @@
 [[2c8u]], [[2cai]] - ShGST (mutant) <br />
+[[3vpt]], [[4e8h]] – siGST <br />
 [[2ca8]] - ShGST + GSH<BR />
 [[2wb9]] - FhGST + GSH<br />
@@ Line 223: / Line 240: @@
 [[1pd2]] - rGST + GSH<BR />
 [[2c80]] - ShGST + GSH derivative<br />
-[[1gsq]] - sqGST + GSH derivative
+[[1gsq]] - sqGST + GSH derivative<br />
+[[3vpq]] – siGST + GSH<br />
+[[3vur]] – siGST + GSH derivative<br />
 ===GST ϑ class===
-[[2ljr]], [[2c3n]] - hGST <br />
+[[2ljr]], [[2c3n]], [[4mpf]] - hGST <br />
 [[2c3t]] - hGST (mutant) <br />
-[[1ljr]] - hGST + GSH<BR />
+[[1ljr]], [[4mpg]] - hGST + GSH<BR />
 [[3mak]] - DmGST + GSH<BR />
 [[3ljr]] - hGST + GSH derivative<br />
@@ Line 241: / Line 260: @@
 [[1eem]] – hGST<br />
-[[3q18]], [[3vln]] - hGST (mutant) <br />
+[[3q18]], [[3vln]], [[4is0]] - hGST (mutant) <br />
 [[3rbt]] - siGST <br />
 [[3lfl]] - hGST + GSH<BR />