2hrt

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[[Image:2hrt.jpg|left|200px]]<br /><applet load="2hrt" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2hrt.jpg|left|200px]]
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caption="2hrt, resolution 3.00&Aring;" />
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'''Asymmetric structure of trimeric AcrB from Escherichia coli'''<br />
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{{Structure
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|PDB= 2hrt |SIZE=350|CAPTION= <scene name='initialview01'>2hrt</scene>, resolution 3.00&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=FLC:CITRATE ANION'>FLC</scene>
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|ACTIVITY=
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|GENE= acrB, acrE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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}}
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'''Asymmetric structure of trimeric AcrB from Escherichia coli'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2HRT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=FLC:'>FLC</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HRT OCA].
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2HRT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HRT OCA].
==Reference==
==Reference==
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Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism., Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM, Science. 2006 Sep 1;313(5791):1295-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16946072 16946072]
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Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism., Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM, Science. 2006 Sep 1;313(5791):1295-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16946072 16946072]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: tolc]]
[[Category: tolc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:45:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:20:46 2008''

Revision as of 15:20, 20 March 2008

Image:2hrt.jpg


PDB ID 2hrt

Drag the structure with the mouse to rotate
, resolution 3.00Å
Ligands:
Gene: acrB, acrE (Escherichia coli)
Coordinates: save as pdb, mmCIF, xml



Asymmetric structure of trimeric AcrB from Escherichia coli


Overview

The AcrA/AcrB/TolC complex spans the inner and outer membranes of Escherichia coli and serves as its major drug-resistance pump. Driven by the proton motive force, it mediates the efflux of bile salts, detergents, organic solvents, and many structurally unrelated antibiotics. Here, we report a crystallographic structure of trimeric AcrB determined at 2.9 and 3.0 angstrom resolution in space groups that allow asymmetry of the monomers. This structure reveals three different monomer conformations representing consecutive states in a transport cycle. The structural data imply an alternating access mechanism and a novel peristaltic mode of drug transport by this type of transporter.

About this Structure

2HRT is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism., Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM, Science. 2006 Sep 1;313(5791):1295-8. PMID:16946072

Page seeded by OCA on Thu Mar 20 17:20:46 2008

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