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Tumor necrosis factor
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| - | <StructureSection load='2az5' size='350' side='right' caption='Structure of human tumor necrosis factor complex with inhibitor (PDB entry [[2az5]])' scene=''> | + | <StructureSection load='2az5' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene=''> |
'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNF alpha converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). | '''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNF alpha converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). | ||
Revision as of 11:30, 24 June 2013
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